From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Polo-like kinase 3 (Drosophila) , also known as PLK3 , is an
enzyme which in humans is encoded by the PLK3
gene .
[5]
[6]
Function
Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of
cell cycle progression and
tumorigenesis .
[5]
Interactions
PLK3 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000173846 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028680 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)" .
^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996).
"Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas" . J. Biol. Chem . 271 (32): 19402–8.
doi :
10.1074/jbc.271.32.19402 .
PMID
8702627 .
^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999).
"The physical association and phosphorylation of Cdc25C protein phosphatase by Prk" . Oncogene . 18 (44): 6029–36.
doi :
10.1038/sj.onc.1202983 .
PMID
10557092 .
^
a
b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene . 21 (43): 6633–40.
doi :
10.1038/sj.onc.1205850 .
PMID
12242661 .
S2CID
24106070 .
^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001).
"Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway" . J. Biol. Chem . 276 (46): 43305–12.
doi :
10.1074/jbc.M106050200 .
PMID
11551930 .
Further reading
Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (1996).
"Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas" . J. Biol. Chem . 271 (32): 19402–8.
doi :
10.1074/jbc.271.32.19402 .
PMID
8702627 .
Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science . 277 (5331): 1501–5.
doi :
10.1126/science.277.5331.1501 .
PMID
9278512 .
Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W (1997).
"Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions" . J. Biol. Chem . 272 (45): 28646–51.
doi :
10.1074/jbc.272.45.28646 .
PMID
9353331 .
Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D (1999).
"The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity" . EMBO J . 18 (20): 5528–39.
doi :
10.1093/emboj/18.20.5528 .
PMC
1171621 .
PMID
10523297 .
Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (1999).
"The physical association and phosphorylation of Cdc25C protein phosphatase by Prk" . Oncogene . 18 (44): 6029–36.
doi :
10.1038/sj.onc.1202983 .
PMID
10557092 .
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000).
"The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites" . Genes Dev . 14 (3): 289–300.
doi :
10.1101/gad.14.3.289 .
PMC
316358 .
PMID
10673501 .
Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P (2000). "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer . 27 (3): 332–6.
doi :
10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K .
PMID
10679924 .
S2CID
20642025 .
Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000).
"Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro" . Proc. Natl. Acad. Sci. U.S.A . 97 (19): 10389–94.
Bibcode :
2000PNAS...9710389M .
doi :
10.1073/pnas.190030497 .
PMC
27034 .
PMID
10973490 .
Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene . 19 (42): 4832–9.
doi :
10.1038/sj.onc.1203845 .
PMID
11039900 .
S2CID
25807289 .
Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature . 411 (6833): 102–7.
Bibcode :
2001Natur.411..102B .
doi :
10.1038/35075107 .
PMID
11333986 .
S2CID
4410763 .
Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001).
"Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway" . J. Biol. Chem . 276 (46): 43305–12.
doi :
10.1074/jbc.M106050200 .
PMID
11551930 .
Latonen L, Taya Y, Laiho M (2001).
"UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts" . Oncogene . 20 (46): 6784–93.
doi :
10.1038/sj.onc.1204883 .
PMID
11709713 .
Ahn JY, Li X, Davis HL, Canman CE (2002).
"Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain" . J. Biol. Chem . 277 (22): 19389–95.
doi :
10.1074/jbc.M200822200 .
PMID
11901158 .
Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM (2002).
"The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase" . Mol. Cell . 9 (3): 515–25.
doi :
10.1016/S1097-2765(02)00473-2 .
PMID
11931760 .
Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W (2002).
"Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity" . Mol. Cell. Biol . 22 (10): 3450–9.
doi :
10.1128/MCB.22.10.3450-3459.2002 .
PMC
133784 .
PMID
11971976 .
Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene . 21 (43): 6633–40.
doi :
10.1038/sj.onc.1205850 .
PMID
12242661 .
S2CID
24106070 .
Tsvetkov L, Xu X, Li J, Stern DF (2003).
"Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody" . J. Biol. Chem . 278 (10): 8468–75.
doi :
10.1074/jbc.M211202200 .
PMID
12493754 .
Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W (2003).
"Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2" . Cell Cycle . 1 (6): 424–9.
doi :
10.4161/cc.1.6.271 .
PMID
12548019 .
Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004).
"Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation" . Oncogene . 23 (15): 2658–63.
doi :
10.1038/sj.onc.1207425 .
PMID
14968113 .
Activity Regulation Classification Kinetics Types