RAC-gamma serine/threonine-protein kinase is an
enzyme that in humans is encoded by the AKT3gene.[5][6]
Function
The protein encoded by this gene is a member of the
AKT subfamily of
serine/threonine protein kinases. AKT kinases are known to be regulators of cell signaling in response to
insulin and
growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation,
apoptosis,
tumorigenesis, as well as
glycogen synthesis and
glucose uptake. This kinase has been shown to be stimulated by
platelet-derived growth factor (PDGF), insulin, and
insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.[7] Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.
^Hodgkinson CP, Sale EM, Sale GJ (2002). "Characterization of PDK2 activity against protein kinase B gamma". Biochemistry. 41 (32): 10351–9.
doi:
10.1021/bi026065r.
PMID12162751.
Murthy SS, Tosolini A, Taguchi T, Testa JR (2000). "Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 38–40.
doi:
10.1159/000015481.
PMID10773662.
S2CID556711.
Kapasi AA, Fan S, Singhal PC (2001). "Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation". Am. J. Physiol. Renal Physiol. 280 (2): F333–42.
doi:
10.1152/ajprenal.2001.280.2.F333.
PMID11208609.
S2CID29992656.
Zinda MJ, Johnson MA, Paul JD, Horn C, Konicek BW, Lu ZH, Sandusky G, Thomas JE, Neubauer BL, Lai MT, Graff JR (2001). "AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon". Clin. Cancer Res. 7 (8): 2475–9.
PMID11489829.
Hodgkinson CP, Sale EM, Sale GJ (2002). "Characterization of PDK2 activity against protein kinase B gamma". Biochemistry. 41 (32): 10351–9.
doi:
10.1021/bi026065r.
PMID12162751.