From Wikipedia, the free encyclopedia
MAP kinase-activated protein kinase 5 is an
enzyme that in
humans is encoded by the MAPKAPK5
gene .
[5]
[6]
The
protein encoded by this gene is a member of the
serine /
threonine kinase family. In
response to cellular stress and
proinflammatory cytokines , this
kinase is activated through its
phosphorylation by
MAP kinases , including
MAPK1 /ERK,
MAPK14 /p38-alpha, and
MAPK11 /p38-beta.
In vitro , this kinase
phosphorylates
heat shock protein
HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct
isoforms have been reported.
[6]
A link between
Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed.
Clinical trials may confirm if this is the case.
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000089022 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000029454 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J (Jul 1998).
"PRAK, a novel protein kinase regulated by the p38 MAP kinase" . EMBO J . 17 (12): 3372–84.
doi :
10.1093/emboj/17.12.3372 .
PMC
1170675 .
PMID
9628874 .
^
a
b
"Entrez Gene: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5" .
Further reading
de Carvalho MG, McCormack AL, Olson E, et al. (1996).
"Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes" . J. Biol. Chem . 271 (12): 6987–97.
doi :
10.1074/jbc.271.12.6987 .
PMID
8636128 .
Börsch-Haubold AG, Bartoli F, Asselin J, et al. (1998).
"Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells" . J. Biol. Chem . 273 (8): 4449–58.
doi :
10.1074/jbc.273.8.4449 .
PMID
9468497 .
Ni H, Wang XS, Diener K, Yao Z (1998). "MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase". Biochem. Biophys. Res. Commun . 243 (2): 492–6.
doi :
10.1006/bbrc.1998.8135 .
PMID
9480836 .
Sudo T, Maruyama M, Osada H (2000). "p62 functions as a p38 MAP kinase regulator". Biochem. Biophys. Res. Commun . 269 (2): 521–5.
doi :
10.1006/bbrc.2000.2333 .
PMID
10708586 .
Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001).
"Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases" . J. Biol. Chem . 275 (48): 37542–51.
doi :
10.1074/jbc.M003395200 .
PMID
10978317 .
Zhou J, Lottenbach KR, Barenkamp SJ, et al. (2002).
"Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F" . Infect. Immun . 70 (8): 4083–91.
doi :
10.1128/IAI.70.8.4083-4091.2002 .
PMC
128163 .
PMID
12117915 .
Perfetti V, Casarini S, Palladini G, et al. (2002).
"Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment" . Blood . 100 (3): 948–53.
doi :
10.1182/blood-2002-01-0114 .
PMID
12130507 .
Knebel A, Haydon CE, Morrice N, Cohen P (2002).
"Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways" . Biochem. J . 367 (Pt 2): 525–32.
doi :
10.1042/BJ20020916 .
PMC
1222910 .
PMID
12171600 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
New L, Jiang Y, Han J (2004).
"Regulation of PRAK subcellular location by p38 MAP kinases" . Mol. Biol. Cell . 14 (6): 2603–16.
doi :
10.1091/mbc.E02-08-0538 .
PMC
194907 .
PMID
12808055 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Sun P, Yoshizuka N, New L, et al. (2007).
"PRAK is essential for ras-induced senescence and tumor suppression" . Cell . 128 (2): 295–308.
doi :
10.1016/j.cell.2006.11.050 .
PMID
17254968 .
S2CID
12383872 .
Activity Regulation Classification Kinetics Types