From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an
enzyme that in humans is encoded by the MAPK12
gene .
[5]
Function
Activation of members of the
mitogen-activated protein kinase family is a major mechanism for
transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of
myoblasts to
myotubes .
[5]
References
Further reading
Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2006).
"Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays" . J. Am. Chem. Soc . 128 (17): 5913–22.
doi :
10.1021/ja060943h .
PMC
2533859 .
PMID
16637659 .
Joneson T, Bar-Sagi D (1997). "Ras effectors and their role in mitogenesis and oncogenesis". J. Mol. Med . 75 (8): 587–93.
doi :
10.1007/s001090050143 .
PMID
9297626 .
S2CID
23541383 .
Hou SW, Zhi HY, Pohl N, et al. (2010).
"PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction" . Cancer Res . 70 (7): 2901–10.
doi :
10.1158/0008-5472.CAN-09-3229 .
PMC
2848905 .
PMID
20332238 .
Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, et al. (2008).
"Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I." J. Gen. Virol . 89 (Pt 7): 1661–71.
doi :
10.1099/vir.0.82971-0 .
PMID
18559936 .
Sabio G, Cerezo-Guisado MI, Del Reino P, et al. (2010).
"p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock" . J. Cell Sci . 123 (Pt 15): 2596–604.
doi :
10.1242/jcs.066514 .
PMC
2908048 .
PMID
20605917 .
Zhang J, Harrison JS, Studzinski GP (2011).
"Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃" . Exp. Cell Res . 317 (1): 117–30.
doi :
10.1016/j.yexcr.2010.08.010 .
PMC
2998239 .
PMID
20804750 .
Kwong J, Hong L, Liao R, et al. (2009).
"p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms" . J. Biol. Chem . 284 (17): 11237–46.
doi :
10.1074/jbc.M808327200 .
PMC
2670128 .
PMID
19251701 .
Morishima-Kawashima M, Hasegawa M, Takio K, et al. (1995). "Hyperphosphorylation of tau in PHF". Neurobiol. Aging . 16 (3): 365–71, discussion 371–80.
doi :
10.1016/0197-4580(95)00027-C .
PMID
7566346 .
S2CID
22471158 .
Diskin R, Askari N, Capone R, et al. (2004).
"Active mutants of the human p38alpha mitogen-activated protein kinase" . J. Biol. Chem . 279 (45): 47040–9.
doi :
10.1074/jbc.M404595200 .
PMID
15284239 .
Askari N, Diskin R, Avitzour M, et al. (2007).
"Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription" . J. Biol. Chem . 282 (1): 91–9.
doi :
10.1074/jbc.M608012200 .
PMID
17088247 .
Krauss RS, Cole F, Gaio U, et al. (2005).
"Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact" . J. Cell Sci . 118 (Pt 11): 2355–62.
doi :
10.1242/jcs.02397 .
PMID
15923648 .
Talmud PJ, Drenos F, Shah S, et al. (2009).
"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip" . Am. J. Hum. Genet . 85 (5): 628–42.
doi :
10.1016/j.ajhg.2009.10.014 .
PMC
2775832 .
PMID
19913121 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
Tosti E, Waldbaum L, Warshaw G, et al. (2004).
"The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway" . J. Biol. Chem . 279 (46): 47652–60.
doi :
10.1074/jbc.M409961200 .
PMID
15342622 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Qi X, Pohl NM, Loesch M, et al. (2007).
"p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response" . J. Biol. Chem . 282 (43): 31398–408.
doi :
10.1074/jbc.M703857200 .
PMID
17724032 .
Collins JE, Wright CL, Edwards CA, et al. (2004).
"A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84.
doi :
10.1186/gb-2004-5-10-r84 .
PMC
545604 .
PMID
15461802 .
Kukkonen-Macchi A, Sicora O, Kaczynska K, et al. (2011). "Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death". J. Cell Sci . 124 (Pt 2): 216–27.
doi :
10.1242/jcs.068254 .
PMID
21172807 .
S2CID
4909652 .
Sofroniew MV, Howe CL,
Mobley WC (2001). "Nerve growth factor signaling, neuroprotection, and neural repair". Annu. Rev. Neurosci . 24 : 1217–81.
doi :
10.1146/annurev.neuro.24.1.1217 .
PMID
11520933 .
Bailey SD, Xie C, Do R, et al. (2010).
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study" . Diabetes Care . 33 (10): 2250–3.
doi :
10.2337/dc10-0452 .
PMC
2945168 .
PMID
20628086 .
Activity Regulation Classification Kinetics Types
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .