From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 11 is an
enzyme that in humans is encoded by the MAPK11
gene .
[5]
[6]
Function
The protein encoded by this gene is a member of the
MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation ,
differentiation ,
transcription regulation , and development. This kinase is most closely related to
p38 MAP kinase , both of which can be activated by proinflammatory
cytokines and environmental stress. This kinase is activated through its phosphorylation by
MAP kinase kinases (
MKKs ), preferably by
MKK6 .
Transcription factor
ATF2/CREB2 has been shown to be a substrate of this kinase.
[6]
Interactions
MAPK11 has been shown to
interact with
HDAC3
[7] and
Promyelocytic leukemia protein .
[8]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000185386 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000053137 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (Aug 1997).
"Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases" . EMBO J . 16 (12): 3563–71.
doi :
10.1093/emboj/16.12.3563 .
PMC
1169981 .
PMID
9218798 .
^
a
b
"Entrez Gene: MAPK11 mitogen-activated protein kinase 11" .
^ Mahlknecht U, Will J, Varin A, Hoelzer D, Herbein G (Sep 2004).
"Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression" . J. Immunol . 173 (6): 3979–90.
doi :
10.4049/jimmunol.173.6.3979 .
PMID
15356147 .
^ Shin J, Park B, Cho S, Lee S, Kim Y, Lee SO, Cho K, Lee S, Jin BS, Ahn JH, Choi EJ, Ahn K (Sep 2004).
"Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase" . J. Biol. Chem . 279 (39): 40994–1003.
doi :
10.1074/jbc.M407369200 .
PMID
15273249 .
External links
Further reading
Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S, Han J (1996).
"Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)" . J. Biol. Chem . 271 (30): 17920–6.
doi :
10.1074/jbc.271.30.17920 .
PMID
8663524 .
Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, Young PR (1997). "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles". Biochem. Biophys. Res. Commun . 235 (3): 533–8.
doi :
10.1006/bbrc.1997.6849 .
PMID
9207191 .
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS (1997).
"p38-2, a novel mitogen-activated protein kinase with distinct properties" . J. Biol. Chem . 272 (31): 19509–17.
doi :
10.1074/jbc.272.31.19509 .
PMID
9235954 .
Enslen H, Raingeaud J, Davis RJ (1998).
"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6" . J. Biol. Chem . 273 (3): 1741–8.
doi :
10.1074/jbc.273.3.1741 .
PMID
9430721 .
New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J (1998).
"PRAK, a novel protein kinase regulated by the p38 MAP kinase" . EMBO J . 17 (12): 3372–84.
doi :
10.1093/emboj/17.12.3372 .
PMC
1170675 .
PMID
9628874 .
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998).
"Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . EMBO J . 17 (15): 4426–41.
doi :
10.1093/emboj/17.15.4426 .
PMC
1170775 .
PMID
9687510 .
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999).
"The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95.
Bibcode :
1999Natur.402..489D .
doi :
10.1038/990031 .
PMID
10591208 .
Lee SH, Park J, Che Y, Han PL, Lee JK (2000). "Constitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain". J. Neurosci. Res . 60 (5): 623–31.
doi :
10.1002/(SICI)1097-4547(20000601)60:5<623::AID-JNR7>3.0.CO;2-4 .
PMID
10820433 .
S2CID
21839143 .
Tanoue T, Yamamoto T, Maeda R, Nishida E (2001).
"A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs" . J. Biol. Chem . 276 (28): 26629–39.
doi :
10.1074/jbc.M101981200 .
PMID
11359773 .
Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, Rosini P, Marlier LN, Bonini P, Dello Sbarba P, Palamara AT, Zambrano N, Russo T, Garaci E, Cozzolino F (2001).
"Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release" (PDF) . J. Biol. Chem . 276 (42): 39027–36.
doi :
10.1074/jbc.M102970200 .
PMID
11495898 .
Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J (2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science . 295 (5558): 1291–4.
Bibcode :
2002Sci...295.1291G .
doi :
10.1126/science.1067289 .
PMID
11847341 .
S2CID
93896233 .
Reunanen N, Li SP, Ahonen M, Foschi M, Han J, Kähäri VM (2002).
"Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization" . J. Biol. Chem . 277 (35): 32360–8.
doi :
10.1074/jbc.M204296200 .
PMID
12060661 .
Knebel A, Haydon CE, Morrice N, Cohen P (2002).
"Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways" . Biochem. J . 367 (Pt 2): 525–32.
doi :
10.1042/BJ20020916 .
PMC
1222910 .
PMID
12171600 .
Kinet S, Bernard F, Mongellaz C, Perreau M, Goldman FD, Taylor N (2002).
"gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes" . Blood . 100 (7): 2546–53.
doi :
10.1182/blood-2002-03-0819 .
PMID
12239168 .
Lim S, Zou Y, Friedman E (2002).
"The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase" . J. Biol. Chem . 277 (51): 49438–45.
doi :
10.1074/jbc.M206840200 .
PMID
12384504 .
Naderi J, Hung M, Pandey S (2003). "Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress". Apoptosis . 8 (1): 91–100.
doi :
10.1023/A:1021657220843 .
PMID
12510156 .
S2CID
19686042 .
Stringaris AK, Geisenhainer J, Bergmann F, Balshüsemann C, Lee U, Zysk G, Mitchell TJ, Keller BU, Kuhnt U, Gerber J, Spreer A, Bähr M, Michel U, Nau R (2002). "Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase". Neurobiol. Dis . 11 (3): 355–68.
doi :
10.1006/nbdi.2002.0561 .
hdl :
11858/00-001M-0000-0012-F282-1 .
PMID
12586546 .
S2CID
25034287 .
Activity Regulation Classification Kinetics Types