From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase (SNARK) is an
enzyme that in humans is encoded by the NUAK2
gene .
[5]
[6] Its deficiency in humans causes
anencephaly , a severe form of anterior
neural tube defect that curtails brain development.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000163545 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000009772 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001).
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35.
doi :
10.1101/gr.GR1547R .
PMC
311072 .
PMID
11230166 .
^
"Entrez Gene: NUAK2 NUAK family, SNF1-like kinase, 2" .
^ Bonnard C, Navaratnam N, Ghosh K, Chan PW, Tan TT, Pomp O, et al. (December 2020).
"A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling" . The Journal of Experimental Medicine . 217 (12).
doi :
10.1084/jem.20191561 .
PMC
7953732 .
PMID
32845958 .
Further reading
Hartley JL, Temple GF, Brasch MA (2001).
"DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Simpson JC, Wellenreuther R, Poustka A, et al. (2001).
"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92.
doi :
10.1093/embo-reports/kvd058 .
PMC
1083732 .
PMID
11256614 .
Lefebvre DL, Bai Y, Shahmolky N, et al. (2001).
"Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK" . Biochem. J . 355 (Pt 2): 297–305.
doi :
10.1042/0264-6021:3550297 .
PMC
1221739 .
PMID
11284715 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family". Biochem. Biophys. Res. Commun . 311 (1): 156–61.
doi :
10.1016/j.bbrc.2003.09.184 .
PMID
14575707 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Lizcano JM, Göransson O, Toth R, et al. (2005).
"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1" . EMBO J . 23 (4): 833–43.
doi :
10.1038/sj.emboj.7600110 .
PMC
381014 .
PMID
14976552 .
Legembre P, Schickel R, Barnhart BC, Peter ME (2004).
"Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness" . J. Biol. Chem . 279 (45): 46742–7.
doi :
10.1074/jbc.M404334200 .
PMID
15345718 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5.
Bibcode :
2005Sci...307.1621B .
doi :
10.1126/science.1105776 .
PMID
15761153 .
S2CID
39457788 .
Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
"The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8.
doi :
10.1093/nar/gkj139 .
PMC
1347501 .
PMID
16381901 .
Activity Regulation Classification Kinetics Types