From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a
protein that in humans is encoded by the GNG3
gene .
[5]
[6]
G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM]
[6]
References
Further reading
Wedegaertner PB, Wilson PT, Bourne HR (1995).
"Lipid modifications of trimeric G proteins" . J. Biol. Chem . 270 (2): 503–6.
doi :
10.1074/jbc.270.2.503 .
PMID
7822269 .
Garcia-Higuera I, Thomas TC, Yi F, Neer EJ (1996).
"Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma" . J. Biol. Chem . 271 (1): 528–35.
doi :
10.1074/jbc.271.1.528 .
PMID
8550614 .
Yan K, Kalyanaraman V, Gautam N (1996).
"Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families" . J. Biol. Chem . 271 (12): 7141–6.
doi :
10.1074/jbc.271.12.7141 .
PMID
8636150 .
Morishita R, Saga S, Kawamura N, et al. (1997).
"Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain" . J. Neurochem . 68 (2): 820–7.
doi :
10.1046/j.1471-4159.1997.68020820.x .
PMID
9003074 .
S2CID
83968908 .
Bell B, Xing H, Yan K, et al. (1999).
"KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation" . J. Biol. Chem . 274 (12): 7982–6.
doi :
10.1074/jbc.274.12.7982 .
PMID
10075696 .
Hurowitz EH, Melnyk JM, Chen YJ, et al. (2000).
"Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes" . DNA Res . 7 (2): 111–20.
doi :
10.1093/dnares/7.2.111 .
PMID
10819326 .
Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001).
"Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq" . J. Biol. Chem . 276 (26): 23945–53.
doi :
10.1074/jbc.M101154200 .
PMID
11294873 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Cuello F, Schulze RA, Heemeyer F, et al. (2003).
"Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta" . J. Biol. Chem . 278 (9): 7220–6.
doi :
10.1074/jbc.M210304200 .
PMID
12486123 .
Kato C, Mizutani T, Tamaki H, et al. (2004).
"Characterization of heterotrimeric G protein complexes in rice plasma membrane" . Plant J . 38 (2): 320–31.
doi :
10.1111/j.1365-313X.2004.02046.x .
PMID
15078334 .
Schwindinger WF, Giger KE, Betz KS, et al. (2004).
"Mice with Deficiency of G Protein γ3 Are Lean and Have Seizures" . Mol. Cell. Biol . 24 (17): 7758–68.
doi :
10.1128/MCB.24.17.7758-7768.2004 .
PMC
506985 .
PMID
15314181 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .