Dual specificity mitogen-activated protein kinase kinase 2 is an
enzyme that in humans is encoded by the MAP2K2gene.[5] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.[6]
Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in
mitogen growth factor signal transduction. It phosphorylates and thus activates
MAPK1/ERK2 and
MAPK3/ERK1.
The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by
MAP kinase kinase kinases.
The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[7]
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PMID9325171.
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PMID9558095.
S2CID31628194.
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PMID9671314.
S2CID7117056.
Overview of all the structural information available in the
PDB for
UniProt: P36507 (Dual specificity mitogen-activated protein kinase kinase 2) at the
PDBe-KB.