From Wikipedia, the free encyclopedia
This list contains a list of
EC numbers for the sixth group, EC 6 ,
ligases , placed in numerical order as determined by the Nomenclature Committee of the
International Union of Biochemistry and Molecular Biology . All official information is tabulated at the website of the committee.
[1] The database is developed and maintained by Andrew McDonald.
[2]
EC 6.1: Forming Carbon-Oxygen Bonds
EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (
Aminoacyl tRNA synthetase )
EC 6.1.2: Acid—alcohol ligases (ester synthases)
* No Wikipedia article
EC 6.1.3: Cyclo-ligases
* No Wikipedia article
EC 6.2: Forming Carbon-Sulfur Bonds
EC 6.2.1: Acid-Thiol Ligases
EC
6.2.1.1 :
acetate—CoA ligase
EC
6.2.1.2 :
medium-chain acyl-CoA ligase
EC
6.2.1.3 :
long-chain-fatty-acid—CoA ligase
EC
6.2.1.4 :
succinate—CoA ligase (GDP-forming)
EC
6.2.1.5 :
succinate—CoA ligase (ADP-forming)
EC
6.2.1.6 :
glutarate—CoA ligase
EC
6.2.1.7 :
cholate—CoA ligase
EC
6.2.1.8 :
oxalate—CoA ligase
EC
6.2.1.9 :
malate—CoA ligase
EC
6.2.1.10 :
carboxylic acid—CoA ligase (GDP-forming)
EC
6.2.1.11 :
biotin—CoA ligase
EC
6.2.1.12 :
4-coumarate—CoA ligase
EC
6.2.1.13 :
acetate—CoA ligase (ADP-forming)
EC
6.2.1.14 :
6-carboxyhexanoate—CoA ligase
EC
6.2.1.15 :
arachidonate—CoA ligase
EC
6.2.1.16 :
acetoacetate—CoA ligase
EC
6.2.1.17 :
propionate—CoA ligase
EC
6.2.1.18 :
citrate—CoA ligase
EC
6.2.1.19 :
long-chain-fatty-acid—protein ligase
EC
6.2.1.20 :
long-chain-fatty-acid—[acyl-carrier-protein] ligase
EC 6.2.1.21: Activity covered by
EC
6.2.1.30 , phenylacetate—CoA ligase
EC
6.2.1.22 :
[citrate (pro -3S )-lyase] ligase
EC
6.2.1.23 :
dicarboxylate—CoA ligase
EC
6.2.1.24 :
phytanate—CoA ligase
EC
6.2.1.25 :
benzoate—CoA ligase
EC
6.2.1.26 :
o -succinylbenzoate—CoA ligase
EC
6.2.1.27 :
4-hydroxybenzoate—CoA ligase
EC
6.2.1.28 :
3α,7α-dihydroxy-5β-cholestanate—CoA ligase
EC 6.2.1.29: Deleted, identical to
EC
6.2.1.7 , cholate—CoA ligase
EC
6.2.1.30 :
phenylacetate—CoA ligase
EC
6.2.1.31 :
2-furoate—CoA ligase
EC
6.2.1.32 :
anthranilate—CoA ligase
EC
6.2.1.33 :
4-chlorobenzoate—CoA ligase
EC
6.2.1.34 :
trans -feruloyl-CoA synthase
EC
6.2.1.35 :
acetate—[acyl-carrier protein] ligase
EC
6.2.1.36 :
3-hydroxypropionyl-CoA synthase
EC
6.2.1.37 :
3-hydroxybenzoate—CoA ligase
EC
6.2.1.38 :
(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
EC
6.2.1.39 :
[butirosin acyl-carrier protein]—L -glutamate ligase
EC
6.2.1.40 : 4-hydroxybutyrate—CoA ligase (AMP-forming) *
EC
6.2.1.41 : 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H -inden-4-yl]propanoate—CoA ligase *
EC
6.2.1.42 : 3-oxocholest-4-en-26-oate—CoA ligase *
EC
6.2.1.43 : 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase *
EC
6.2.1.44 : 3-(methylthio)propionyl—CoA ligase *
EC
6.2.1.45 : E1 ubiquitin-activating enzyme *
EC
6.2.1.46 : L -allo -isoleucine—holo-[CmaA peptidyl-carrier protein] ligase *
EC
6.2.1.47 : medium-chain-fatty-acid—[acyl-carrier-protein] ligase *
EC
6.2.1.48 : carnitine—CoA ligase *
EC
6.2.1.49 : long-chain fatty acid adenylyltransferase FadD28 *
EC
6.2.1.50 : 4-hydroxybenzoate adenylyltransferase FadD22 *
EC
6.2.1.51 : 4-hydroxyphenylalkanoate adenylyltransferase FadD29 *
EC
6.2.1.52 : L -firefly luciferin—CoA ligase *
EC
6.2.1.53 : L -proline—[L -prolyl-carrier protein] ligase *
EC
6.2.1.54 : D -alanine—[D -alanyl-carrier protein] ligase *
EC
6.2.1.55 : E1 SAMP-activating enzyme *
EC
6.2.1.56 : 4-hydroxybutyrate—CoA ligase (ADP-forming) *
EC
6.2.1.57 : long-chain fatty acid adenylase/transferase FadD23 *
EC
6.2.1.58 : isophthalate—CoA ligase *
EC
6.2.1.59 : long-chain fatty acid adenylase/transferase FadD26 *
EC
6.2.1.60 : marinolic acid—CoA ligase *
EC
6.2.1.61 : salicylate—[aryl-carrier protein] ligase *
EC
6.2.1.62 : 3,4-dihydroxybenzoate—[aryl-carrier protein] ligase *
EC
6.2.1.63 : L -arginine—[L -arginyl-carrier protein] ligase *
EC
6.2.1.64 : E1 NEDD8-activating enzyme *
EC
6.2.1.65 : salicylate—CoA ligase *
EC
6.2.1.66 : glyine—[glycyl-carrier protein] ligase *
EC
6.2.1.67 : L -alanine—[L -alanyl-carrier protein] ligase *
EC
6.2.1.68 : L -glutamate—[L -glutamyl-carrier protein] ligase *
EC
6.2.1.69 : L -cysteine—[L -cysteinyl-carrier protein] ligase *
EC
6.2.1.70 : L -threonine—[L -threonyl-carrier protein] ligase *
EC
6.2.1.71 : 2,3-dihydroxybenzoate—[aryl-carrier protein] ligase *
EC
6.2.1.72 : L -serine—[L -seryl-carrier protein] ligase *
EC
6.2.1.73 : L -tryptophan—[L -tryptophyl-carrier protein] ligase *
EC
6.2.1.74 : 3-amino-5-hydroxybenzoate—[acyl-carrier protein] ligase *
+
EC
6.2.1.75 : indoleacetate—CoA ligase
* No Wikipedia article
EC 6.2.2: Amide—thiol ligases
* No Wikipedia article
EC 6.3: Forming Carbon-Nitrogen Bonds
EC 6.3.1: Acid—Ammonia (or Amine) Ligases (Amide Synthases)
* No Wikipedia article
EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)
EC
6.3.2.1 :
pantoate—β-alanine ligase (AMP-forming)
EC
6.3.2.2 :
glutamate—cysteine ligase
EC
6.3.2.3 :
glutathione synthase
EC
6.3.2.4 :
D -alanine—D -alanine ligase
EC
6.3.2.5 :
phosphopantothenate—cysteine ligase (CTP)
EC
6.3.2.6 :
phosphoribosylaminoimidazolesuccinocarboxamide synthase
EC
6.3.2.7 :
UDP-N -acetylmuramoyl-L -alanyl-D -glutamate—L -lysine ligase
EC
6.3.2.8 :
UDP-N -acetylmuramate—L -alanine ligase
EC
6.3.2.9 :
UDP-N -acetylmuramoyl-L -alanine—D -glutamate ligase
EC
6.3.2.10 :
UDP-N -acetylmuramoyl-tripeptide—D -alanyl-D -alanine ligase
EC
6.3.2.11 :
carnosine synthase
EC
6.3.2.12 :
dihydrofolate synthase
EC
6.3.2.13 :
UDP-N -acetylmuramoyl-L -alanyl-D -glutamate—2,6-diaminopimelate ligase
EC
6.3.2.14 :
enterobactin synthase
EC 6.3.2.15: Deleted, The activity observed is due to
EC
6.3.2.10 , UDP-N -acetylmuramoyl-tripeptideD -alanyl-D -alanine ligase
EC
6.3.2.16 :
D -alanine—alanyl-poly(glycerolphosphate) ligase
EC
6.3.2.17 :
tetrahydrofolate synthase
EC
6.3.2.18 :
γ-glutamylhistamine synthase
EC 6.3.2.19: The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with
EC
6.2.1.45 (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of
EC
2.3.2.23 (E2 ubiquitin-conjugating enzyme) and
EC
2.3.2.27 (RING-type E3 ubiquitin transferase)
EC
6.3.2.20 :
indoleacetate—lysine synthetase
EC 6.3.2.21: The reaction is performed by the sequential action of
EC
6.2.1.45 (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by
EC
2.3.2.27 [ubiquitin transferase RING E3 (calmodulin-selective)]
EC 6.3.2.22: Now
EC
6.3.1.14 , diphthine—ammonia ligase.
EC
6.3.2.23 :
homoglutathione synthase
EC
6.3.2.24 :
tyrosine—arginine ligase
EC
6.3.2.25 :
tubulin—tyrosine ligase
EC
6.3.2.26 :
N -(5-amino-5-carboxypentanoyl)-L -cysteinyl-D -valine synthase
EC 6.3.2.27: The activity is covered by two independent enzymes,
EC
6.3.2.38 N 2 -citryl-N 6 -acetyl-N 6 -hydroxylysine synthase, and
EC
6.3.2.39 , aerobactin synthase
EC 6.3.2.28: Now
EC
6.3.2.49 , L -alanine-L -anticapsin ligase
EC
6.3.2.29 :
cyanophycin synthase (L -aspartate-adding)
EC
6.3.2.30 :
cyanophycin synthase (L -arginine-adding)
EC
6.3.2.31 :
coenzyme F420 -0:L -glutamate ligase
EC
6.3.2.32 :
coenzyme γ-F420 -2:α-L -glutamate ligase
EC
6.3.2.33 :
tetrahydrosarcinapterin synthase
EC
6.3.2.34 :
coenzyme F420 -0:L -glutamate ligase
EC
6.3.2.35 :
D -alanine—D -serine ligase
EC
6.3.2.36 :
4-phosphopantoate—β-alanine ligase
EC
6.3.2.37 :
UDP-N-acetylmuramoyl-L -alanyl-D -glutamate—D -lysine ligase
EC
6.3.2.38 :
N 2 -citryl-N 6 -acetyl-N 6 -hydroxylysine synthase
EC
6.3.2.39 :
aerobactin synthase
EC
6.3.2.40 : cyclopeptine synthase *
EC
6.3.2.41 : N -acetylaspartylglutamate synthase *
EC
6.3.2.42 : N -acetylaspartylglutamylglutamate synthase *
EC
6.3.2.43 : [amino-group carrier protein]—L -2-aminoadipate ligase *
EC
6.3.2.44 : pantoate—β-alanine ligase (ADP-forming) *
EC
6.3.2.45 : UDP-N -acetylmuramate—L -alanyl-γ-D -glutamyl-meso-2,6-diaminoheptanedioate ligase *
EC
6.3.2.46 : fumarate—(S )-2,3-diaminopropanoate ligase *
EC
6.3.2.47 : dapdiamide synthase *
EC
6.3.2.48 : L -arginine-specific L -amino acid ligase *
EC
6.3.2.49 : L -alanine—L -anticapsin ligase *
EC
6.3.2.50 : tenuazonic acid synthetase *
EC
6.3.2.51 : phosphopantothenate—cysteine ligase (ATP) *
EC
6.3.2.52 : jasmonoyl—L -amino acid ligase *
EC
6.3.2.53 : UDP-N -acetylmuramoyl-L -alanine—L -glutamate ligase *
EC
6.3.2.54 : L -2,3-diaminopropanoate—citrate ligase *
EC
6.3.2.55 : 2-[(L -alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase *
EC
6.3.2.56 : staphyloferrin B synthase *
EC
6.3.2.57 : staphyloferrin A synthase *
EC
6.3.2.58 : D -ornithine—citrate ligase *
EC
6.3.2.59 : 3-methyl-D -ornithine—L -lysine ligase *
EC
6.3.2.60 : glutamate—[amino group carrier protein] ligase *
EC
6.3.2.61 : tubulin-glutamate ligase *
EC
6.3.2.62 : β-tubulin-glutamate ligase *
* No Wikipedia article
EC 6.3.3: Cyclo-Ligases
* No Wikipedia article
EC 6.3.4: Other Carbon-Nitrogen Ligases
* No Wikipedia article
EC 6.3.5: Carbon-nitrogen ligases with glutamine as amido-N -donor
* No Wikipedia article
EC 6.4: Forming Carbon-Carbon Bonds
EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
*No Wikipedia article
EC 6.5: Forming Phosphoric Ester Bonds
EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
* No Wikipedia article
EC 6.6: Forming Nitrogen-Metal Bonds
EC 6.6.1: Forming Coordination Complexes
EC 6.7: Forming nitrogen-nitrogen bonds
EC 6.7.1: Forming diazo bonds
EC
6.7.1.1 : 3-amino-2-hydroxy-4-methoxybenzoate *
* No Wikipedia article
Activity Regulation Classification Kinetics Types
6.1 : Carbon-Oxygen
6.2 : Carbon-Sulfur
6.3 : Carbon-Nitrogen
6.5 : Phosphoric Ester
6.6 : Nitrogen-Metal
References