5'-AMP-activated protein kinase subunit gamma-1 is an
enzyme that in humans is encoded by the PRKAG1gene.[5][6][7]
Function
The protein encoded by this gene is a regulatory subunit of the
AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus
phosphorylates and inactivates
acetyl-CoA carboxylase (ACC) and
beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of
fatty acid and
cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.
Alternatively spliced transcript variants encoding distinct
isoforms have been observed.[7]
Reinton N, Haugen TB, Orstavik S, Skålhegg BS, Hansson V, Jahnsen T, Taskén K (April 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics. 49 (2): 290–7.
doi:
10.1006/geno.1998.5240.
PMID9598317.
Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (July 1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Research and Human Retroviruses. 14 (10): 825–33.
doi:
10.1089/aid.1998.14.825.
PMID9671211.
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92.
doi:
10.1159/000026336.
PMID9730685.
S2CID19529677.
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB (April 2004). "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus". Nature. 428 (6982): 569–74.
Bibcode:
2004Natur.428..569M.
doi:
10.1038/nature02440.
PMID15058305.
S2CID4302317.
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human 5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1)