From Wikipedia, the free encyclopedia
In
enzymology, a myosin-heavy-chain kinase (
EC
2.7.11.7) is an
enzyme that
catalyzes the
chemical reaction
- ATP + [myosin heavy-chain] ADP + [myosin heavy-chain] phosphate
Thus, the two
substrates of this enzyme are
ATP and
myosin heavy-chain, whereas its two
products are
ADP and
myosin heavy-chain phosphate.
This enzyme belongs to the family of
transferases, specifically those transferring a phosphate group to the sidechain
oxygen atom of
serine or
threonine residues in
proteins (
protein-serine/threonine kinases). The
systematic name of this enzyme class is ATP:[myosin heavy-chain] O-phosphotransferase. Other names in common use include
- ATP:myosin-heavy-chain O-phosphotransferase
- calmodulin-dependent myosin heavy chain kinase
- MHCK
- MIHC kinase
- myosin heavy chain kinase
- myosin I heavy-chain kinase
- myosin II heavy-chain kinase
- [myosin-heavy-chain] kinase
- myosin heavy chain kinase A
- STK6.
References
- Cote GP, Bukiejko U (1987).
"Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum". J. Biol. Chem. 262 (3): 1065–72.
doi:
10.1016/S0021-9258(19)75750-0.
PMID
3027076.
- Hammer JA III, Albanesi JP, Korn ED (1983).
"Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii". J. Biol. Chem. 258 (16): 10168–75.
doi:
10.1016/S0021-9258(17)44620-5.
PMID
6309772.
- Rieker JP, Swanljung-Collins H, Collins JH (1987).
"Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border". J. Biol. Chem. 262 (31): 15262–8.
doi:
10.1016/S0021-9258(18)48169-0.
PMID
2822719.
- Ravid S, Spudich JA (1989).
"Myosin heavy chain kinase from developed Dictyostelium cells Purification and characterization". J. Biol. Chem. 264 (25): 15144–50.
doi:
10.1016/S0021-9258(18)63823-2.
PMID
2549052.
- Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED (1990).
"Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides". J. Biol. Chem. 265 (27): 16138–44.
doi:
10.1016/S0021-9258(17)46199-0.
PMID
2168881.
- Ravid S, Spudich JA (1992).
"Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5877–81.
Bibcode:
1992PNAS...89.5877R.
doi:
10.1073/pnas.89.13.5877.
PMC
49400.
PMID
1321427.
- Futey LM, Medley QG, Cote GP, Egelhoff TT (1995).
"Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins". J. Biol. Chem. 270 (2): 523–9.
doi:
10.1074/jbc.270.2.523.
PMID
7822274.
- Korn ED, Brzeska H (1998).
"Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4146–51.
Bibcode:
1998PNAS...95.4146S.
doi:
10.1073/pnas.95.8.4146.
PMC
22456.
PMID
9539704.
- Egelhoff TT, Croft D, Steimle PA (2005).
"Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly". J. Biol. Chem. 280 (4): 2879–87.
doi:
10.1074/jbc.M410803200.
PMID
15545285.
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