From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
cAMP-dependent protein kinase catalytic subunit gamma is an
enzyme that in humans is encoded by the PRKACG
gene .
[3]
[4]
[5]
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is
intronless and is thought to be a
retrotransposon derived from the gene for the alpha form of the PKA
catalytic subunit .
[5]
Interactions
PRKACG has been shown to
interact with
Ryanodine receptor 2 .
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000165059 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990).
"Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase" . Mol Endocrinol . 4 (3): 465–75.
doi :
10.1210/mend-4-3-465 .
PMID
2342480 .
^ Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics . 49 (2): 290–7.
doi :
10.1006/geno.1998.5240 .
PMID
9598317 .
^
a
b
"Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma" .
^ Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks A R (May 2000).
"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts" . Cell . 101 (4). UNITED STATES: 365–76.
doi :
10.1016/S0092-8674(00)80847-8 .
ISSN
0092-8674 .
PMID
10830164 .
S2CID
6496567 .
Further reading
Foss KB, Simard J, Bérubé D, Beebe S, Sandberg M, Grzeschik KH, Gagné R, Hansson V, Jahnsen T (1992). "Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13". Cytogenet. Cell Genet . 60 (1): 22–5.
doi :
10.1159/000133286 .
PMID
1339328 .
Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL (1991).
"HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism" . J. Immunol . 145 (11): 3699–705.
doi :
10.4049/jimmunol.145.11.3699 .
PMID
1978848 .
Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL (1993).
"Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes" . Proc. Natl. Acad. Sci. U.S.A . 90 (14): 6676–80.
Bibcode :
1993PNAS...90.6676H .
doi :
10.1073/pnas.90.14.6676 .
PMC
46995 .
PMID
7688126 .
Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS . 8 (7): 1016–7.
doi :
10.1097/00002030-199407000-00025 .
PMID
7946090 .
Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D (1997).
"The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix" . J. Virol . 71 (6): 4372–7.
doi :
10.1128/JVI.71.6.4372-4377.1997 .
PMC
191654 .
PMID
9151826 .
Chen P, Mayne M, Power C, Nath A (1997).
"The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases" . J. Biol. Chem . 272 (36): 22385–8.
doi :
10.1074/jbc.272.36.22385 .
PMID
9278385 .
Liapi C, Takahashi N, Raynaud F, Evain-Brion D, Anderson WB (1998).
"Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts" . J. Invest. Dermatol . 110 (4): 332–7.
doi :
10.1046/j.1523-1747.1998.00149.x .
PMID
9540970 .
Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses . 14 (10): 825–33.
doi :
10.1089/aid.1998.14.825 .
PMID
9671211 .
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation . 5 (3–4): 184–92.
doi :
10.1159/000026336 .
PMID
9730685 .
S2CID
19529677 .
Bodnar RJ, Xi X, Li Z, Berndt MC, Du X (2003).
"Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta)" . J. Biol. Chem . 277 (49): 47080–7.
doi :
10.1074/jbc.M208329200 .
PMID
12361948 .
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Cartier C, Hemonnot B, Gay B, Bardy M, Sanchiz C, Devaux C, Briant L (2003).
"Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein" . J. Biol. Chem . 278 (37): 35211–9.
doi :
10.1074/jbc.M301257200 .
PMID
12842892 .
Masci AM, Galgani M, Cassano S, De Simone S, Gallo A, De Rosa V, Zappacosta S, Racioppi L (2004).
"HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling" . J. Leukoc. Biol . 74 (6): 1117–24.
doi :
10.1189/jlb.0503239 .
PMID
12972513 .
S2CID
13393007 .
Zhang W, Morris GZ, Beebe SJ (2004). "Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells". Protein Expr. Purif . 35 (1): 156–69.
doi :
10.1016/j.pep.2004.01.006 .
PMID
15039079 .
Stevanin G, Hahn V, Lohmann E, Bouslam N, Gouttard M, Soumphonphakdy C, Welter ML, Ollagnon-Roman E, Lemainque A (2004).
"Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14" . Arch. Neurol . 61 (8): 1242–8.
doi :
10.1001/archneur.61.8.1242 .
PMID
15313841 .
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Activity Regulation Classification Kinetics Types