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Protein-coding gene in the species Homo sapiens
Large tumor suppressor kinase 2 (LATS2) is an
enzyme that in humans is encoded by the LATS2
gene .
[5]
[6]
This gene encodes a
serine/threonine protein kinase belonging to the LATS
tumor suppressor family and participates in the
Hippo signaling pathway where it inactivates the effector proteins, YAP and
WWTR1 (TAZ) . The protein localizes to
centrosomes during
interphase and early and late
metaphase . It interacts with the centrosomal proteins
aurora-A and
ajuba and is required for accumulation of
gamma-tubulin and
spindle formation at the onset of
mitosis . It also interacts with a
negative regulator of
p53 and may function in a
positive feedback loop with p53 that responds to
cytoskeleton damage. Additionally, it can function as a
corepressor of
androgen-responsive gene expression.
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000150457 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000021959 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics . 63 (2): 263–70.
doi :
10.1006/geno.1999.6065 .
PMID
10673337 .
^
a
b
"Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)" .
Further reading
Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000).
"Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor" . Oncogene . 19 (27): 3101–9.
doi :
10.1038/sj.onc.1203659 .
PMID
10871863 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Li Y, Pei J, Xia H, et al. (2003).
"Lats2, a putative tumor suppressor, inhibits G1/S transition" . Oncogene . 22 (28): 4398–405.
doi :
10.1038/sj.onc.1206603 .
PMID
12853976 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Powzaniuk M, McElwee-Witmer S, Vogel RL, et al. (2005).
"The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor" . Mol. Endocrinol . 18 (8): 2011–23.
doi :
10.1210/me.2004-0065 .
PMID
15131260 .
Toji S, Yabuta N, Hosomi T, et al. (2005).
"The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase" . Genes Cells . 9 (5): 383–97.
doi :
10.1111/j.1356-9597.2004.00732.x .
PMID
15147269 .
Ke H, Pei J, Ni Z, et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)". Exp. Cell Res . 298 (2): 329–38.
doi :
10.1016/j.yexcr.2004.04.031 .
PMID
15265683 .
Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene . 24 (12): 2076–86.
doi :
10.1038/sj.onc.1208445 .
PMID
15688006 .
S2CID
27285160 .
Takahashi Y, Miyoshi Y, Takahata C, et al. (2005).
"Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers" . Clin. Cancer Res . 11 (4): 1380–5.
doi :
10.1158/1078-0432.CCR-04-1773 .
PMID
15746036 .
Abe Y, Ohsugi M, Haraguchi K, et al. (2006).
"LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis" . FEBS Lett . 580 (3): 782–8.
doi :
10.1016/j.febslet.2005.12.096 .
PMID
16413547 .
Voorhoeve PM, le Sage C, Schrier M, et al. (2006).
"A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors" . Cell . 124 (6): 1169–81.
doi :
10.1016/j.cell.2006.02.037 .
PMID
16564011 .
Aylon Y, Michael D, Shmueli A, et al. (2007).
"A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization" . Genes Dev . 20 (19): 2687–700.
doi :
10.1101/gad.1447006 .
PMC
1578695 .
PMID
17015431 .
Jiang Z, Li X, Hu J, et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma". Neurosci. Res . 56 (4): 450–8.
doi :
10.1016/j.neures.2006.09.006 .
PMID
17049657 .
S2CID
22763208 .
Activity Regulation Classification Kinetics Types