GNG13 References

GNG13
Identifiers
Aliases	GNG13, G(gamma)13, h2-35, G protein subunit gamma 13, HG3J
External IDs	OMIM: 607298 MGI: 1925616 HomoloGene: 81890 GeneCards: GNG13
Gene location ( Human)
Chr.	Chromosome 16 (human)
End	800,734 bp
Gene location ( Mouse)
Chr.	Chromosome 17 (mouse)
End	25,938,380 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; prefrontal cortex; ; amygdala; ; hypothalamus; ; inferior ganglion of vagus nerve; ; cerebellar vermis; ; superior frontal gyrus; ; duodenum; ; substantia nigra; ; postcentral gyrus;
	Top expressed in
	olfactory epithelium; ; cerebellar vermis; ; visual cortex; ; superior frontal gyrus; ; temporal lobe; ; motor neuron; ; primary motor cortex; ; prefrontal cortex; ; amygdala; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G-protein beta-subunit binding; signal transducer activity; GTPase activity;
Cellular component	plasma membrane; dendrite; membrane; heterotrimeric G-protein complex;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; sensory perception of taste; signal transduction;
	Sources: Amigo / QuickGO
Orthologs
	51764
	64337
	ENSG00000127588
	ENSMUSG00000025739
	Q9P2W3
	Q9JMF3
	NM_016541
	NM_022422; NM_001357782
	NP_057625
	NP_071867; NP_001344711
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is a protein that in humans is encoded by the GNG13 gene.^[5]^[6]

Interactions

GNG13 has been shown to interact with GNB5.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127588 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025739 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF (Jan 2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat Neurosci. 2 (12): 1055–62. doi: 10.1038/15981. PMID 10570481. S2CID 24494794.
^ "Entrez Gene: GNG13 guanine nucleotide binding protein (G protein), gamma 13".
^ Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (Dec 2001). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi: 10.1074/jbc.M106565200. PMID 11675383.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791. PMID 8889548.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339. PMID 11157797.
Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (2002). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi: 10.1074/jbc.M106565200. PMID 11675383.
Huang L, Max M, Margolskee RF, Su H, Masland RH, Euler T (2003). "G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells". J. Comp. Neurol. 455 (1): 1–10. doi: 10.1002/cne.10396. PMID 12454992. S2CID 22270368.
Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi: 10.1074/jbc.M210304200. PMID 12486123.
Kato C, Mizutani T, Tamaki H, Kumagai H, Kamiya T, Hirobe A, Fujisawa Y, Kato H, Iwasaki Y (2004). "Characterization of heterotrimeric G protein complexes in rice plasma membrane". Plant J. 38 (2): 320–31. doi: 10.1111/j.1365-313X.2004.02046.x. PMID 15078334.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi: 10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins". J. Biol. Chem. 281 (16): 11066–73. doi: 10.1074/jbc.M600113200. PMID 16473877.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127588 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025739 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10570481-5] Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF (Jan 2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat Neurosci. 2 (12): 1055–62. doi: 10.1038/15981. PMID 10570481. S2CID 24494794.

[entrez-6] "Entrez Gene: GNG13 guanine nucleotide binding protein (G protein), gamma 13".

[pmid11675383-7] Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (Dec 2001). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi: 10.1074/jbc.M106565200. PMID 11675383.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Interactions

References

Further reading