From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
TTK
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
2X9E ,
2ZMC ,
2ZMD ,
3CEK ,
3DBQ ,
3GFW ,
3H9F ,
3HMN ,
3HMO ,
3HMP ,
3VQU ,
3W1F ,
3WYX ,
3WYY ,
3WZJ ,
3WZK ,
4B94 ,
4BHZ ,
4BI0 ,
4BI1 ,
4BI2 ,
4C4E ,
4C4G ,
4C4H ,
4C4I ,
4C4J ,
4CV8 ,
4CV9 ,
4CVA ,
4D2S ,
4H7X ,
4H7Y ,
4JS8 ,
4JT3 ,
4O6L ,
5AP0 ,
5AP1 ,
5AP2 ,
5AP3 ,
5AP4 ,
5AP5 ,
5AP6 ,
5AP7 ,
5EI2 ,
5EHY ,
5EH0 ,
5EI6 ,
4ZEG ,
5EI8
Identifiers
Aliases
TTK , CT96, ESK, MPH1, MPS1, MPS1L1, PYT, TTK protein kinaseExternal IDs
OMIM :
604092
MGI :
1194921
HomoloGene :
2489
GeneCards :
TTK
Wikidata
Dual specificity protein kinase TTK also known as Mps1 is an
enzyme that in humans is encoded by the TTK
gene .
[5]
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000112742 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000038379 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992).
"Expression of TTK, a novel human protein kinase, is associated with cell proliferation" . J Biol Chem . 267 (22): 16000–6.
doi :
10.1016/S0021-9258(19)49633-6 .
PMID
1639825 .
^
"Entrez Gene: TTK TTK protein kinase" .
Further reading
Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members". Protein Phosphorylation Part A: Protein Kinases: Assays, Purification, Antibodies, Functional Analysis, Cloning, and Expression . Methods in Enzymology. Vol. 200. pp. 38–62.
doi :
10.1016/0076-6879(91)00126-H .
ISBN
978-0-12-182101-2 .
PMID
1956325 .
Lindberg RA, Fischer WH, Hunter T (1993). "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene . 8 (2): 351–9.
PMID
7678926 .
Lauzé E, Stoelcker B, Luca FC, et al. (1995).
"Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase" . EMBO J . 14 (8): 1655–63.
doi :
10.1002/j.1460-2075.1995.tb07154.x .
PMC
398258 .
PMID
7737118 .
Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999).
"Characterization of MAD2B and other mitotic spindle checkpoint genes" . Genomics . 58 (2): 181–7.
doi :
10.1006/geno.1999.5831 .
PMID
10366450 .
Weinmann AS, Yan PS, Oberley MJ, et al. (2002).
"Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis" . Genes Dev . 16 (2): 235–44.
doi :
10.1101/gad.943102 .
PMC
155318 .
PMID
11799066 .
Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002).
"Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication" . EMBO J . 21 (7): 1723–32.
doi :
10.1093/emboj/21.7.1723 .
PMC
125937 .
PMID
11927556 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Liu ST, Chan GK, Hittle JC, et al. (2003).
"Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores" . Mol. Biol. Cell . 14 (4): 1638–51.
doi :
10.1091/mbc.02-05-0074 .
PMC
153128 .
PMID
12686615 .
Fisk HA, Mattison CP, Winey M (2004).
"Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression" . Proc. Natl. Acad. Sci. U.S.A . 100 (25): 14875–80.
doi :
10.1073/pnas.2434156100 .
PMC
299837 .
PMID
14657364 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Dou Z, Ding X, Zereshki A, et al. (2004).
"TTK kinase is essential for the centrosomal localization of TACC2" . FEBS Lett . 572 (1–3): 51–6.
doi :
10.1016/j.febslet.2004.06.092 .
PMID
15304323 .
S2CID
8403635 .
Wei JH, Chou YF, Ou YH, et al. (2005).
"TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68" . J. Biol. Chem . 280 (9): 7748–57.
doi :
10.1074/jbc.M410152200 .
PMID
15618221 .
Camacho E, Beà S, Salaverría I, et al. (2006).
"Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma" . Int. J. Cancer . 118 (2): 357–63.
doi :
10.1002/ijc.21370 .
PMID
16080195 .
S2CID
7968793 .
Leng M, Chan DW, Luo H, et al. (2006).
"MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability" . Proc. Natl. Acad. Sci. U.S.A . 103 (31): 11485–90.
Bibcode :
2006PNAS..10311485L .
doi :
10.1073/pnas.0601828103 .
PMC
1518802 .
PMID
16864798 .
Bertheau P, Turpin E, Rickman DS, et al. (2007).
"Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen" . PLOS Med . 4 (3): e90.
doi :
10.1371/journal.pmed.0040090 .
PMC
1831731 .
PMID
17388661 .
Zhu S, Wang W, Clarke DC, Liu X (2007).
"Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling" . J. Biol. Chem . 282 (25): 18327–38.
doi :
10.1074/jbc.M700636200 .
PMID
17452325 .
Kanai M, Ma Z, Izumi H, et al. (2007).
"Physical and functional interaction between mortalin and Mps1 kinase" . Genes Cells . 12 (6): 797–810.
doi :
10.1111/j.1365-2443.2007.01091.x .
PMID
17573779 .
S2CID
342866 .
Mattison CP, Old WM, Steiner E, et al. (2007).
"Mps1 activation loop autophosphorylation enhances kinase activity" . J. Biol. Chem . 282 (42): 30553–61.
doi :
10.1074/jbc.M707063200 .
PMID
17728254 .
Activity Regulation Classification Kinetics Types