Tribbles homolog 2 is an atypical
protein kinase that is encoded in human by the TRIB2gene.[5][6][7][8] TRIB2 is a
pseudokinase member of the (
pseudoenzyme) class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro.[9] It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models.[10] Like
TRIB1 and
TRIB3, TRIB2 has recently been considered as a potential allosteric drug target,[11]
[12] and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation [13] High levels of autoantibodies against TRIB2 in Hcrt neurons (in lateral and posterior hypothalamus) seem also closely related to some cases of narcolepsy + cataplexy (N+C) [14]
^Foulkes DM, Byrne DP, Eyers PA (2015). "Tribbles pseudokinases: novel targets for chemical biology and drug discovery?". Biochemical Society Transactions. 43 (5): 1095–1103.
doi:
10.1042/BST20150109.
PMID26517930.
Zhang Y, Davis JL, Li W (2005). "Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display". Mol. Immunol. 42 (11): 1275–81.
doi:
10.1016/j.molimm.2004.11.020.
PMID15950723.
