From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Protein kinase C beta type is an
enzyme that in humans is encoded by the PRKCB
gene .
[5]
Protein kinase C (PKC) is a family of
serine - and
threonine -specific
protein
kinases that can be activated by
calcium and
second messenger
diacylglycerol . PKC family members
phosphorylate a wide variety of protein targets and are known to be involved in diverse
cellular signaling pathways. PKC family members also serve as major receptors for
phorbol
esters , a class of
tumor promoters . Each member of the PKC family has a specific
expression profile and is believed to play a distinct role in
cells . The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as
B cell activation,
apoptosis induction,
endothelial cell
proliferation , and
intestinal
sugar absorption. Studies in
mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress.
Alternatively spliced
transcript variants encoding distinct
isoforms have been reported.
[6] This gene could be associated with
autism .
[7]
[8]
Interactions
PRKCB1 has been shown to
interact with
RIPK4 ,
[9]
beta adrenergic receptor kinase ,
[10]
PDLIM5
[11] and
GNB2L1 .
[12]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000166501 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000052889 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kubo K, Ohno S, Suzuki K (September 1987).
"Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II" . Nucleic Acids Research . 15 (17): 7179–80.
doi :
10.1093/nar/15.17.7179 .
PMC
306204 .
PMID
3658678 .
^
"Entrez Gene: PRKCB1 protein kinase C, beta 1" .
^ Philippi A, Roschmann E, Tores F, Lindenbaum P, Benajou A, Germain-Leclerc L, et al. (October 2005).
"Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism" . Molecular Psychiatry . 10 (10): 950–60.
doi :
10.1038/sj.mp.4001704 .
PMID
16027742 .
^ Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, et al. (July 2009).
"Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression" . Molecular Psychiatry . 14 (7): 705–18.
doi :
10.1038/mp.2008.21 .
PMID
18317465 .
^ Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S (June 2001).
"Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase" . The Journal of Biological Chemistry . 276 (24): 21737–44.
doi :
10.1074/jbc.M008069200 .
PMID
11278382 .
^ Yang XL, Zhang YL, Lai ZS, Xing FY, Liu YH (April 2003).
"Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase" . World Journal of Gastroenterology . 9 (4): 800–3.
doi :
10.3748/wjg.v9.i4.800 .
PMC
4611453 .
PMID
12679936 .
^ Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, et al. (December 1996).
"Protein-protein interaction of zinc finger LIM domains with protein kinase C" . The Journal of Biological Chemistry . 271 (49): 31029–32.
doi :
10.1074/jbc.271.49.31029 .
PMID
8940095 .
^ Ron D, Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (September 1999).
"Coordinated movement of RACK1 with activated betaIIPKC" . The Journal of Biological Chemistry . 274 (38): 27039–46.
doi :
10.1074/jbc.274.38.27039 .
PMID
10480917 .
Further reading
Activity Regulation Classification Kinetics Types