Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an
enzyme that in humans is encoded by the MAPK10gene.[5][6][7]
Function
The protein encoded by this gene is a member of the
MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its
phosphorylation and
nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal
apoptosis.
Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by
MAP kinase kinase 4 (MKK4).
Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Jabado N, Pallier A, Jauliac S, Fischer A, Hivroz C (1997). "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes". Eur. J. Immunol. 27 (2): 397–404.
doi:
10.1002/eji.1830270209.
PMID9045910.
S2CID23787450.
Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P, Flavell RA (1997). "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene". Nature. 389 (6653): 865–70.
Bibcode:
1997Natur.389..865Y.
doi:
10.1038/39899.
PMID9349820.
S2CID4430535.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Lannuzel A, Barnier JV, Hery C, Huynh VT, Guibert B, Gray F, Vincent JD, Tardieu M (1997). "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons". Ann. Neurol. 42 (6): 847–56.
doi:
10.1002/ana.410420605.
PMID9403476.
S2CID36951375.
Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P (2000). "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1". Biochemistry. 39 (11): 3141–8.
doi:
10.1021/bi992410.
PMID10715136.
McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ (2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science. 290 (5496): 1574–7.
Bibcode:
2000Sci...290.1574M.
doi:
10.1126/science.290.5496.1574.
PMID11090355.
1jnk: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
1pmn: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
1pmq: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
1pmu: The crystal structure of JNK3 in complex with a phenantroline inhibitor
1pmv: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
1ukh: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
1uki: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
2b1p: inhibitor complex of JNK3
2exc: Inhibitor complex of JNK3
2g01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
2gmx: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
2no3: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
2o0u: Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
2o2u: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
2ok1: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide