From Wikipedia, the free encyclopedia
Imetit
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Names
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IUPAC name
2-(1H-imidazol-5-yl)ethyl carbamimidothioate
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Identifiers
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ChEMBL
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ChemSpider
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UNII
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InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10) NKey: PEHSVUKQDJULKE-UHFFFAOYSA-N NInChI=1/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10) Key: PEHSVUKQDJULKE-UHFFFAOYAJ
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C1=C(NC=N1)CCSC(=N)N S(C(=[N@H])N)CCc1cnc[nH]1
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Properties
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C6H10N4S
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Molar mass
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170.2354 g/mol
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Imetit is a
histamine H3 receptor
agonist.
[1]
References
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^ Garbarg, M; Arrang, JM; Rouleau, A; Ligneau, X; Tuong, MD; Schwartz, JC; Ganellin, CR (1992). "S-2-(4-imidazolyl)ethylisothiourea, a highly specific and potent histamine H3 receptor agonist". The Journal of Pharmacology and Experimental Therapeutics. 263 (1): 304–10.
PMID
1383495.
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H1 | Agonists | |
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Antagonists |
- Others:
Atypical antipsychotics (e.g.,
aripiprazole,
asenapine,
brexpiprazole,
brilaroxazine,
clozapine,
iloperidone,
olanzapine,
paliperidone,
quetiapine,
risperidone,
ziprasidone,
zotepine)
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Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone,
nefazodone,
trazodone,
triazoledione)
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Tetracyclic antidepressants (e.g.,
amoxapine,
loxapine,
maprotiline,
mianserin,
mirtazapine,
oxaprotiline)
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Tricyclic antidepressants (e.g.,
amitriptyline,
butriptyline,
clomipramine,
desipramine,
dosulepin (dothiepin),
doxepin,
imipramine,
iprindole,
lofepramine,
nortriptyline,
protriptyline,
trimipramine)
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Typical antipsychotics (e.g.,
chlorpromazine,
flupenthixol,
fluphenazine,
loxapine,
perphenazine,
prochlorperazine,
thioridazine,
thiothixene)
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H2 | |
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H3 | |
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H4 | |
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