From Wikipedia, the free encyclopedia
Chemical compound
NS-2359 (GSK-372475 ) is a
serotonin-norepinephrine-dopamine reuptake inhibitor . It was under
development by
GlaxoSmithKline (GSK) as an
antidepressant ,
[1] but was discontinued in 2009 when
phase II
clinical trials showed the drug was not effective and not well tolerated.
[2] The results did not support further effort by the company.
[1] NS-2359 was also in clinical trials for the
treatment of
ADHD ,
[3] phase II having been completed in 2007.
[4] A
phase I clinical trial exploring the effect of NS-2359 on
cocaine -
dependent individuals was completed in 2002.
[5]
See also
References
^
a
b
"NeuroSearch announces the results of Phase II Proof of Concept studies with NS2359 in depression" . NeuroSearch.
^ Learned S, Graff O, Roychowdhury S, Moate R, Krishnan KR, Archer G, Modell JG, Alexander R, Zamuner S, Lavergne A, Evoniuk G, Ratti E (May 2012). "Efficacy, safety, and tolerability of a triple reuptake inhibitor GSK372475 in the treatment of patients with major depressive disorder: two randomized, placebo- and active-controlled clinical trials". Journal of Psychopharmacology . 26 (5): 653–62.
doi :
10.1177/0269881111424931 .
PMID
22048884 .
S2CID
9365152 .
^ Wilens TE, Klint T, Adler L, West S, Wesnes K, Graff O, Mikkelsen B (June 2008).
"A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHD" . Behavioral and Brain Functions . 4 : 24.
doi :
10.1186/1744-9081-4-24 .
PMC
2442604 .
PMID
18554401 .
^ Clinical trial number
NCT00467428 for "Efficacy and Safety of NS2359 in Adults With Attention Deficit Hyperactivity Disorder" at
ClinicalTrials.gov
^ Clinical trial number
NCT00032916 for "Interaction Study With NS2359 and Cocaine in Cocaine Experienced Volunteers" at
ClinicalTrials.gov
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