From Wikipedia, the free encyclopedia
SNDRI antidepressant drug
Ansofaxine
Other names LY03005; LPM570065; 4-Methylbenzoate desvenlafaxine
Routes of administration
By mouth
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate
CAS Number
PubChem
CID
ChemSpider
UNII
Formula C 24 H 31 N O 3
Molar mass 381.516 g·mol−1 3D model (
JSmol )
Cc1ccc(cc1)C(=O)Oc2ccc(cc2)C(CN(C)C)C3(CCCCC3)O
InChI=1S/C24H31NO3/c1-18-7-9-20(10-8-18)23(26)28-21-13-11-19(12-14-21)22(17-25(2)3)24(27)15-5-4-6-16-24/h7-14,22,27H,4-6,15-17H2,1-3H3
Key:QKYBZJLEMOZFFU-UHFFFAOYSA-N
Toludesvenlafaxine , also formerly known as ansofaxine and sold under the brand name Ruoxinlin , is an
antidepressant which is approved for the treatment of
major depressive disorder in
China .
[1] It is also under development for use in other countries like the
United States .
[1] It is a
serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and was developed by Luye Pharma Group.
[1]
[2]
[3]
[4]
Toludesvenlafaxine is described as an SNDRI and
prodrug to
desvenlafaxine .
[2] However, unlike desvenlafaxine, which has
in vitro
IC50 Tooltip half-maximal inhibitory concentration values of 53 nM and 538 nM for inhibition of
serotonin and
norepinephrine
reuptake , respectively, toludesvenlafaxine has respective in vitro IC50 values of 723 nM, 763 nM, and 491 nM for serotonin, norepinephrine, and
dopamine reuptake inhibition.
[2] As such, toludesvenlafaxine appears to be a more balanced reuptake inhibitor of serotonin, norepinephrine, and dopamine than desvenlafaxine.
[2]
As of July 2018, toludesvenlafaxine is in preregistration for the treatment of depression in the
United States , the
European Union , and
Japan .
[1] As of January 2023, it is also in
phase 3 clinical trials for the treatment of
generalized anxiety disorder .
[1] In March 2020, the United States
Food and Drug Administration accepted Luye Pharma's
New Drug Application for toludesvenlafaxine, which remains under review.
[1]
[5] In November 2022, toludesvenlafaxine was approved for the treatment of depression in China under the brand name Ruoxinlin.
[6]
[7]
References
^
a
b
c
d
e
f
"Toludesvenlafaxine extended release - Luye Pharma" . AdisInsight . Springer Nature Switzerland AG.
^
a
b
c
d Zhang R, Li X, Shi Y, Shao Y, Sun K, Wang A, et al. (2014).
"The effects of LPM570065, a novel triple reuptake inhibitor, on extracellular serotonin, dopamine and norepinephrine levels in rats" . PLOS ONE . 9 (3): e91775.
Bibcode :
2014PLoSO...991775Z .
doi :
10.1371/journal.pone.0091775 .
PMC
3948889 .
PMID
24614602 .
^ Dale E, Bang-Andersen B, Sánchez C (May 2015).
"Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs" . Biochemical Pharmacology . 95 (2): 81–97.
doi :
10.1016/j.bcp.2015.03.011 .
PMID
25813654 .
^
Completion of Phase 1 Clinical Studies of Ansofaxine Hydrochloride Extended Release Tablets (LY03005) in the U.S.
^
"Luye Pharma Releases Top-Line Results from a Phase II Clinical Trial of Its New Antidepressant Ansofaxine Hydrochloride Extended-Release Tablets" . BioSpace . Retrieved 2022-02-08 .
^
"Luye Pharma's Class 1 Innovative Antidepressant Ruoxinlin® Approved for Launch in China - Press Releases - Luye Pharma Group" . www.luye.cn . Retrieved 2022-12-04 .
^
"R&D - Luye Pharma Group" . www.luye.cn . Retrieved 2022-10-06 .
External links
SSRIs Tooltip Selective serotonin reuptake inhibitors
SNRIs Tooltip Serotonin–norepinephrine reuptake inhibitors
NRIs Tooltip Norepinephrine reuptake inhibitors
NDRIs Tooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAs Tooltip Noradrenergic and specific serotonergic antidepressants
SARIs Tooltip Serotonin antagonist and reuptake inhibitors
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TCAs Tooltip Tricyclic antidepressants
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MAOA Tooltip Monoamine oxidase A -selective
MAOB Tooltip Monoamine oxidase B -selective
DAT Tooltip Dopamine transporter (
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NET Tooltip Norepinephrine transporter (
NRIs Tooltip Norepinephrine reuptake inhibitors )
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