From Wikipedia, the free encyclopedia
Tretoquinol
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Names
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Preferred IUPAC name
(1S)-1-[(3,4,5-Trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
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Identifiers
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ChEMBL
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ChemSpider
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MeSH
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Tretoquinol
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UNII
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InChI=1S/C19H23NO5/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14/h7-10,14,20-22H,4-6H2,1-3H3/t14-/m0/s1 YKey: RGVPOXRFEPSFGH-AWEZNQCLSA-N YInChI=1/C19H23NO5/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14/h7-10,14,20-22H,4-6H2,1-3H3/t14-/m0/s1 Key: RGVPOXRFEPSFGH-AWEZNQCLBM
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O(c1cc(cc(OC)c1OC)C[C@H]3c2c(cc(O)c(O)c2)CCN3)C
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Properties
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C19H23NO5
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Molar mass
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345.39 g/mol
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Pharmacology
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R03AC09 (
WHO)
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Tretoquinol is a
beta-adrenergic agonist.
[1]
[2]
References
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^ Yamato, E.; Hirakura, M.; Sugasawa, S. (1966). "Synthesis of 6,7-dihydrox-1,2,3,4-tetrahydroisoquinoline derivatives". Tetrahedron. 22: 129–134.
doi:
10.1016/S0040-4020(01)82177-3.
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^ Konkar, A. A.; Vansal, S. S.; Shams, G.; Fraundorfer, P. F.; Zheng, W. P.; Nikulin, V. I.; De Los Angeles, J.; Fertel, R. H.; Miller, D. D.; Feller, D. R. (1999-11-01).
"β-Adrenoceptor Subtype Activities of Trimetoquinol Derivatives: Biochemical Studies on Human β-Adrenoceptors Expressed in Chinese Hamster Ovary Cells". The Journal of Pharmacology and Experimental Therapeutics. 291 (2). Jpet.aspetjournals.org: 875–883.
PMID
10525112. Retrieved 2012-08-20.
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α1 | Agonists | |
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Antagonists |
-
Abanoquil
-
Ajmalicine
-
Alfuzosin
-
Anisodamine
-
Anisodine
-
Atiprosin
-
Atypical antipsychotics (e.g.,
brexpiprazole,
clozapine,
olanzapine,
quetiapine,
risperidone)
-
Benoxathian
-
Beta blockers (e.g.,
adimolol,
amosulalol,
arotinolol,
carvedilol,
eugenodilol,
labetalol)
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Buflomedil
-
Bunazosin
-
Corynanthine
-
Dapiprazole
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Domesticine
-
Doxazosin
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Ergolines (e.g.,
acetergamine,
ergotamine,
dihydroergotamine,
lisuride,
nicergoline,
terguride)
-
Etoperidone
-
Fenspiride
-
Hydroxyzine
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Indoramin
-
Ketanserin
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L-765,314
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mCPP
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Mepiprazole
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Metazosin
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Monatepil
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Moxisylyte
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Naftopidil
-
Nantenine
-
Neldazosin
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Niaprazine
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Niguldipine
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Pardoprunox
-
Pelanserin
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Perlapine
-
Phendioxan
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Phenoxybenzamine
-
Phentolamine
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Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone,
nefazodone,
trazodone,
triazoledione)
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Piperoxan
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Prazosin
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Quinazosin
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Quinidine
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Silodosin
-
Spegatrine
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Spiperone
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Talipexole
-
Tamsulosin
-
Terazosin
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Tiodazosin
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Tolazoline
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Tetracyclic antidepressants (e.g.,
amoxapine,
maprotiline,
mianserin)
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Tricyclic antidepressants (e.g.,
amitriptyline,
clomipramine,
doxepin,
imipramine,
trimipramine)
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Trimazosin
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Typical antipsychotics (e.g.,
chlorpromazine,
fluphenazine,
loxapine,
thioridazine)
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Urapidil
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WB-4101
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Zolertine
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α2 | Agonists | |
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Antagonists |
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1-PP
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Adimolol
-
Amesergide
-
Aptazapine
-
Atipamezole
-
Atypical antipsychotics (e.g.,
asenapine,
brexpiprazole,
clozapine,
lurasidone,
olanzapine,
paliperidone,
quetiapine,
risperidone,
zotepine)
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Azapirones (e.g.,
buspirone,
gepirone,
ipsapirone,
tandospirone)
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BRL-44408
-
Buflomedil
-
Cirazoline
-
Efaroxan
-
Esmirtazapine
-
Fenmetozole
-
Fluparoxan
-
Idazoxan
-
Ketanserin
-
Lisuride
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mCPP
-
Mianserin
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Mirtazapine
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NAN-190
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Pardoprunox
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Phentolamine
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Phenoxybenzamine
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Piperoxan
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Piribedil
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Rauwolscine
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Rotigotine
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Setiptiline
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Spegatrine
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Spiroxatrine
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Sunepitron
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Terguride
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Tolazoline
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Typical antipsychotics (e.g.,
chlorpromazine,
fluphenazine,
loxapine,
thioridazine)
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Yohimbine
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β | |
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