In an experiment performed by Clineschidt and colleagues, they dosed mice with varying concentrations of MK-212, and observed its effects.[4]
The result correlated very well to binding of indolealkylamine receptors, such as the
serotonin and
tryptamine receptors, which shows four characteristics. Namely, increased frequency of muscle twitching,
increased twitching of the head,[5] "an increase in the strength of the crossed extensor reflex in the acutely spinalized rat", and the cause of complex motor syndrome.[4]
^Bastani B, Nash JF, Meltzer HY (September 1990). "Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder". Archives of General Psychiatry. 47 (9): 833–9.
doi:
10.1001/archpsyc.1990.01810210041006.
PMID2203327.
^Lowy MT, Meltzer HY (April 1988). "Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist". Biological Psychiatry. 23 (8): 818–28.
doi:
10.1016/0006-3223(88)90070-4.
PMID3365458.
S2CID32736259.
^
abClineschmidt BV, Mcguffin JC, Pflueger AB (July 1977). "Central serotonin-like activity of 6-chloro-2-[1-piperazinyl]-pyrazine (CPP; MK-212)". European Journal of Pharmacology. 44 (1): 65–74.
doi:
10.1016/0014-2999(77)90117-0.
PMID885160.