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Chemical compound
Amibegron
Routes of administration Oral
ATC code
Legal status
Ethyl ([(7S )-7-([(2R )-2-(3-chlorophenyl)-2-hydroxyethyl]amino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)acetate
CAS Number
PubChem
CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (
EPA )
Formula C 22 H 26 Cl N O 4
Molar mass 403.90 g·mol−1 3D model (
JSmol )
CCOC(=O)COc3ccc1CCC(Cc1c3)NCC(O)c2cc(Cl)ccc2
InChI=1S/C22H26ClNO4.ClH/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16;/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3;1H/t19-,21-;/m0./s1
Y Key:NQIZCDQCNYCVAS-RQBPZYBGSA-N
Y
(verify)
Amibegron (SR-58,611A ) was a drug developed by Sanofi-Aventis (now
Sanofi ) which acts as a selective
agonist for the
β3 adrenergic receptor . It is the first orally active β3 agonist developed that is capable of entering the
central nervous system , and has
antidepressant and
anxiolytic effects.
[1]
[2]
On July 31, 2008, Sanofi-Aventis announced that it has decided to discontinue development of amibegron.
[3]
References
^ Stemmelin J, Cohen C, Terranova JP, Lopez-Grancha M, Pichat P, Bergis O, et al. (February 2008).
"Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders" . Neuropsychopharmacology . 33 (3): 574–87.
doi :
10.1038/sj.npp.1301424 .
PMID
17460614 .
^ Overstreet DH, Stemmelin J, Griebel G (June 2008). "Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression". Pharmacology, Biochemistry, and Behavior . 89 (4): 623–6.
doi :
10.1016/j.pbb.2008.02.020 .
PMID
18358519 .
S2CID
35026036 .
^
Second quarter 2008 results . July 31, 2008, retrieved March 9, 2009.
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