From Wikipedia, the free encyclopedia
Class of chemical compounds
Substituted piperazines are a class of
chemical compounds based on a
piperazine core.
[1] Some are used as
recreational drugs and some are used in
scientific research.
[2]
List of substituted piperazines
Benzylpiperazines
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Methoxypiperamide (MeOP, MEXP) ((4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone)
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Sunifiram (1-benzoyl-4-propanoylpiperazine)
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Befuraline(also produces benzylpiperazine as a metabolite)
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Fipexide(also produces substituted benzylpiperazine as a metabolite)
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Piberaline(also produces benzylpiperazine as a metabolite)
Phenylpiperazines
ortho-Substituted
Enpiprazole is known to produce oCPP as a metabolite.
Enciprazine was initially anticipated to produce oMeOPP as a metabolite, but this turned out not to be the case.
meta-Substituted
Trazodone,
nefazodone,
mepiprazole, and others produce mCPP as a metabolite.
para-Substituted
Multiple substitutions
Others
Other arylpiperazines
Many
azapirones such as
buspirone,
gepirone, and
tandospirone produce 1-PP as a
metabolite.
See also
References
-
^ Laras, Y.; Garino, C.; Dessolin, J.; Weck, C.; Moret, V.; Rolland, A.; Kraus, J.-L. (2009-02-01).
"New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors". Journal of Enzyme Inhibition and Medicinal Chemistry. 24 (1): 181–187.
doi:
10.1080/14756360802048939.
ISSN
1475-6366.
PMID
18770069.
S2CID
85385527.
-
^ Alghamdi, Saad; Alshehri, Mohammed M.; Asif, Mohammad (2022).
"The Neuropharmacological Potential of Piperazine Derivatives: A Mini- Review". Mini-Reviews in Organic Chemistry. 19 (7): 798–810.
doi:
10.2174/1570193x19666220119120211.
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Simple piperazines (no additional rings) | |
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Phenylpiperazines |
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2C-B-PP
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3,4-CFP
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Acaprazine
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Antrafenine
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Aripiprazole
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Batoprazine
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Bifeprunox
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BRL-15,572
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Ciprofloxacin
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CSP-2503
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Dapiprazole
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DCPP
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DMPP
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Diphenylpiperazine
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Dropropizine
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EGIS-12,233
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Elopiprazole
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Eltoprazine
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Enpiprazole
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Ensaculin
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Etoperidone
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Flesinoxan
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Fluanisone
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Flibanserin
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Fluprazine
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Itraconazole
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Ketoconazole
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Levodropropizine
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Lorpiprazole
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mCPP
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Mefway
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MeOPP
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Mepiprazole
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Naftopidil
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Naluzotan
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Naphthylpiperazine
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Nefazodone
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Niaprazine
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Oxypertine
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Pardoprunox
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pCPP
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pFPP
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Posaconazole
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S-14,506
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S-14,671
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S-15,535
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SB-258,585
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SB-271,046
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SB-357,134
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SB-399,885
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Sonepiprazole
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TFMPP
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Tolpiprazole
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Trazodone
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Urapidil
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Vesnarinone
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Vilazodone
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Vortioxetine
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WAY-100,135
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WAY-100,635
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Benzylpiperazines | |
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Diphenylalkylpiperazines (benzhydrylalkylpiperazines) | |
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Pyrimidinylpiperazines | |
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Pyridinylpiperazines | |
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Benzo(iso)thiazolyl
piperazines | |
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Tricyclics (piperazine attached via side chain) | |
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Others/Uncategorized | |
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