BRL-44408 is a drug used in scientific research which acts as a selective
antagonist for the
α2A adrenoreceptor.[1] It has been suggested as having potential therapeutic application in the treatment of
extrapyramidal side effects produced by some
antipsychotic medications.[2]
References
^Alberts P (January 1993). "Subtype classification of presynaptic alpha 2-adrenoceptors". General Pharmacology. 24 (1): 1–8.
doi:
10.1016/0306-3623(93)90003-g.
PMID8387042.
^Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). "Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders". Neuroscience Letters. 454 (2): 143–7.
doi:
10.1016/j.neulet.2009.03.001.
PMID19429072.
S2CID38109591.