From Wikipedia, the free encyclopedia
Chemical compound
Minaprine (
INN ,
USAN ,
BAN ; brand names Brantur , Cantor ) is a
monoamine oxidase inhibitor
antidepressant drug
[2] that was used in
France for the treatment of
depression until it was
withdrawn from the market in 1996 because it caused
convulsions .
[3]
A study found that it acts as a
reversible inhibitor of MAO-A (RIMA) in rats.
[4] It has also been found to weakly
inhibit
acetylcholinesterase in rat brain (striatum) homogenates.
[5]
It has demonstrated significant antibiotic activity against
M. chelonae and
M. abscessus in tests with
antibiotic resistant bacteria.
[6]
Minaprine is a member of
pyridazines , a secondary
amine and a member of
morpholines . It has a role as an
antidepressant , a
serotonin uptake inhibitor, a
dopamine uptake inhibitor, a
cholinergic drug and an
antiparkinson drug .
[7]
References
^
Anvisa (2023-03-31).
"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
Diário Oficial da União (published 2023-04-04).
Archived from the original on 2023-08-03. Retrieved 2023-08-16 .
^
"Minaprine - an overview | ScienceDirect Topics" . www.sciencedirect.com . Retrieved 2023-12-14 .
^ Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E (1 January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science . 35 (1): 293–317.
doi :
10.1177/009286150103500134 .
S2CID
73036562 .
^ Kan JP, Mouget-Goniot C, Worms P, Biziere K (March 1986). "Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat". Biochemical Pharmacology . 35 (6): 973–978.
doi :
10.1016/0006-2952(86)90085-7 .
PMID
3954800 .
^ Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG (February 1999). "Aminopyridazines as acetylcholinesterase inhibitors". Journal of Medicinal Chemistry . 42 (4): 730–741.
doi :
10.1021/jm981101z .
PMID
10052979 .
^ Chopra S, Matsuyama K, Hutson C, Madrid P (July 2011).
"Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae" . The Journal of Antimicrobial Chemotherapy . 66 (7): 1533–1536.
doi :
10.1093/jac/dkr154 .
PMID
21486854 .
^ PubChem.
"Minaprine" . pubchem.ncbi.nlm.nih.gov . Retrieved 2023-12-14 .
SSRIs Tooltip Selective serotonin reuptake inhibitors
SNRIs Tooltip Serotonin–norepinephrine reuptake inhibitors
NRIs Tooltip Norepinephrine reuptake inhibitors
NDRIs Tooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAs Tooltip Noradrenergic and specific serotonergic antidepressants
SARIs Tooltip Serotonin antagonist and reuptake inhibitors
SMS Tooltip Serotonin modulator and stimulators Others
TCAs Tooltip Tricyclic antidepressants
TeCAs Tooltip Tetracyclic antidepressants Others
Non-selective
MAOA Tooltip Monoamine oxidase A -selective
MAOB Tooltip Monoamine oxidase B -selective