From Wikipedia, the free encyclopedia
Exaprolol
Names
IUPAC name
1-(2-Cyclohexylphenoxy)-3-(propan-2-ylamino)propan-2-ol
Other names
Esprolol
Identifiers
ChemSpider
KEGG
UNII
InChI=1S/C18H29NO2/c1-14(2)19-12-16(20)13-21-18-11-7-6-10-17(18)15-8-4-3-5-9-15/h6-7,10-11,14-16,19-20H,3-5,8-9,12-13H2,1-2H3
Key: ABXHHEZNIJUQFM-UHFFFAOYSA-N
CC(C)NCC(COC1=CC=CC=C1C2CCCCC2)O
Properties
C 18 H 29 N O 2
Molar mass
291.435 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Exaprolol is a
beta-adrenoceptor antagonist .
[1]
Synthesis
Exaprolol synthesis
[2]
References
^ Van Waarde, A; Doorduin, J; De Jong, JR; Dierckx, RA; Elsinga, PH (2008). "Synthesis and preliminary evaluation of (S)-11C-exaprolol, a novel beta-adrenoceptor ligand for PET". Neurochemistry International . 52 (4–5): 729–33.
doi :
10.1016/j.neuint.2007.09.009 .
PMID
17961850 .
^ Carissimi, M; Gentili, P; Grumelli, E; Milla, E; Picciola, G; Ravenna, F (1976). "Basic ethers of cyclohexylphenols with beta-blocking activity: Synthesis and pharmacological study of exaprolol". Arzneimittel-Forschung . 26 (4): 506–16.
PMID
8056 .
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