SR 59230A is a selective antagonist of the
beta-3 adrenergic receptor,[1][2][3] but was subsequently shown to also act at α1 adrenoceptors at high doses.[4] It has been shown to block the
hyperthermia produced by
MDMA in animal studies.[5]
References
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^Bellantuono V, Cassano G, Lippe C (August 2008). "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp. Biochem. Physiol. C. 148 (2): 160–4.
doi:
10.1016/j.cbpc.2008.05.001.
PMID18544474.
^Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM (January 2008). "Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation". Surgery. 143 (1): 94–102.
doi:
10.1016/j.surg.2007.06.034.
PMID18154937.
^Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B (April 2004). "Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery". J. Pharmacol. Exp. Ther. 309 (1): 137–45.
doi:
10.1124/jpet.103.061192.
PMID14718590.
S2CID394120.