From Wikipedia, the free encyclopedia
Chemical compound
Bucindolol is a
non-selective
beta blocker with additional weak
alpha-blocking properties and
intrinsic sympathomimetic activity in some model systems
[1]
[2] but not in human hearts.
[3]
[4] It was under review by the
FDA in the
United States for the treatment of
heart failure in 2009, but was rejected due to issues pertaining to integrity of data submitted.
[5]
See also
References
-
^
"formularyjournal.modernmedicine.com". Archived from
the original on 2012-03-04.
-
^ Willette RN, Mitchell MP, Ohlstein EH, Lukas MA, Ruffolo RR (January 1998).
"Evaluation of intrinsic sympathomimetic activity of bucindolol and carvedilol in rat heart". Pharmacology. 56 (1): 30–6.
doi:
10.1159/000028179.
PMID
9467185.
S2CID
46848815.
-
^ Bristow MR, Roden RL, Lowes BD, Gilbert EM, Eichhorn EJ (December 1998).
"The role of third-generation beta-blocking agents in chronic heart failure". Clinical Cardiology. 21 (S1): I3–I13.
doi:
10.1002/clc.4960211303.
PMC
6656140.
PMID
9853189.
-
^ Hershberger RE, Wynn JR, Sundberg L, Bristow MR (June 1990).
"Mechanism of Action of Bucindolol in Human Ventricular Myocardium". Journal of Cardiovascular Pharmacology. 15 (6): 959–967.
doi:
10.1097/00005344-199006000-00014.
PMID
1694919.
-
^
"FDA rejects bucindolol and questions trial integrity « CardioBrief". 2 June 2009.
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Yohimbine
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