From Wikipedia, the free encyclopedia
Ridazolol
Names
IUPAC name
5-Chloro-4-[2-[[3-(2-chlorophenoxy)-2-hydroxypropyl]amino]ethylamino]-1H -pyridazin-6-one
Identifiers
ChEMBL
ChemSpider
UNII
InChI=1S/C15H18Cl2N4O3/c16-11-3-1-2-4-13(11)24-9-10(22)7-18-5-6-19-12-8-20-21-15(23)14(12)17/h1-4,8,10,18,22H,5-7,9H2,(H2,19,21,23)
Key: UUWABVCZFXKHSU-UHFFFAOYSA-N
InChI=1/C15H18Cl2N4O3/c16-11-3-1-2-4-13(11)24-9-10(22)7-18-5-6-19-12-8-20-21-15(23)14(12)17/h1-4,8,10,18,22H,5-7,9H2,(H2,19,21,23)
Key: UUWABVCZFXKHSU-UHFFFAOYAL
C1=CC=C(C(=C1)OCC(CNCCNC2=C(C(=O)NN=C2)Cl)O)Cl
Properties
C 15 H 18 Cl 2 N 4 O 3
Molar mass
373.23 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Ridazolol is a pharmaceutical drug acting as a
beta adrenergic receptor antagonist . It was investigated in the 1980 and 90s for its effects on
coronary heart disease and
essential hypertension (high blood pressure).
[1]
[2]
It is not known to be marketed anywhere in the world.
[3]
References
^ Fach, WA; Starke, E; Becker, HJ (1992). "Duration of the effect and dose-response relationship of ridazolol in patients with coronary heart disease". Zeitschrift für Kardiologie . 81 (6): 320–5.
PMID
1353933 .
^ Rommel, Th.; Demisch, L. (1994). "Influence of chronic ?-adrenoreceptor blocker treatment on melatonin secretion and sleep quality in patients with essential hypertension". Journal of Neural Transmission . 95 (1): 39–48.
doi :
10.1007/BF01283029 .
PMID
7857585 .
S2CID
31936176 .
^
"Ridazolol search results" . Drugs.com. Retrieved 2021-03-31 .
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β