From Wikipedia, the free encyclopedia
Chemical compound
Impromidine
ATC code
2-[3-(1H -imidazol-5-yl)propyl]-1-[2-[(5-methyl-1H -imidazol-4-yl)methylsulfanyl]ethyl]guanidine
CAS Number
PubChem
CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (
EPA )
Formula C 14 H 23 N 7 S
Molar mass 321.45 g·mol−1 3D model (
JSmol )
Cc1[nH]cnc1CSCCNC(=N)NCCCc2c[nH]cn2
InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)
N Key:MURRAGMMNAYLNA-UHFFFAOYSA-N
N
N Y
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Impromidine (
INN ) is a highly potent and specific histamine
H2 receptor
agonist .
[1]
It has been used diagnostically as a gastric secretion indicator.
See also
References
^ Durant G, Duncan W, Ganellin C, Parsons M, Blakemore R, Rasmussen A (1978). "Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors".
Nature . 276 (5686): 403–5.
doi :
10.1038/276403a0 .
PMID
714166 .
S2CID
4242863 .
H1
Agonists Antagonists
Others:
Atypical antipsychotics (e.g.,
aripiprazole ,
asenapine ,
brexpiprazole ,
brilaroxazine ,
clozapine ,
iloperidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
ziprasidone ,
zotepine )
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Tetracyclic antidepressants (e.g.,
amoxapine ,
loxapine ,
maprotiline ,
mianserin ,
mirtazapine ,
oxaprotiline )
Tricyclic antidepressants (e.g.,
amitriptyline ,
butriptyline ,
clomipramine ,
desipramine ,
dosulepin (dothiepin) ,
doxepin ,
imipramine ,
iprindole ,
lofepramine ,
nortriptyline ,
protriptyline ,
trimipramine )
Typical antipsychotics (e.g.,
chlorpromazine ,
flupenthixol ,
fluphenazine ,
loxapine ,
perphenazine ,
prochlorperazine ,
thioridazine ,
thiothixene )
H2
H3
H4