The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C
gene.[5] ACVR1C is a type I receptor for the
TGFB family of signaling molecules.[5]
ACVR1C transduces signals of
Nodal.
Nodal binds to
ACVR2B and then forms a complex with ACVR1C. These go on to recruit the
R-SMADsSMAD2 or
SMAD3.[6]
Upon ligand binding, type I receptors
phosphorylate cytoplasmic
SMAD family
transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^
abcBondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3–4): 157–62.
doi:
10.1159/000059339.
PMID12063393.
S2CID30962803.
^Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74.
doi:
10.1124/mol.62.1.65.
PMID12065756.
S2CID15185199.
Tsuchida K, Nakatani M, Yamakawa N, et al. (2004). "Activin isoforms signal through type I receptor serine/threonine kinase ALK7". Mol. Cell. Endocrinol. 220 (1–2): 59–65.
doi:
10.1016/j.mce.2004.03.009.
PMID15196700.
S2CID25170545.