From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a
protein that in humans is encoded by the GDF10
gene .
[5]
GDF10 belongs to the
transforming growth factor beta superfamily that is closely related to
bone morphogenetic protein -3 (
BMP3 ). It plays a role in head formation and may have multiple roles in skeletal
morphogenesis .
[5]
[6] GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.
[5]
In mice, GDF10 mRNA is abundant in the
brain ,
inner ear ,
uterus ,
prostate ,
neural tissues ,
blood vessels and
adipose tissue with low expression in
spleen and
liver . It is also present in bone of both adults and
neonatal mice.
[5] Human GDF10 mRNA is found in the cochlea and lung of
foetuses , and in
testis ,
retina ,
pineal gland , and other neural tissues of adults.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000266524 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000021943 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
c
d Cunningham NS, Jenkins NA, Gilbert DJ, Copeland NG, Reddi AH, Lee SJ (1995). "Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3". Growth Factors . 12 (2): 99–109.
doi :
10.3109/08977199509028956 .
PMID
8679252 .
^ Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S (2004).
"Bone morphogenetic protein-3 family members and their biological functions" . Front Biosci . 9 (1–3): 1520–9.
doi :
10.2741/1355 .
PMID
14977563 .
^ Katoh Y, Katoh M (2006).
"Comparative integromics on BMP/GDF family" . Int J Mol Med . 17 (5): 951–5.
doi :
10.3892/ijmm.17.5.951 .
PMID
16596286 .
Further reading
Davila S, Froeling FE, Tan A, et al. (2010).
"New genetic associations detected in a host response study to hepatitis B vaccine" . Genes Immun . 11 (3): 232–8.
doi :
10.1038/gene.2010.1 .
PMID
20237496 .
Ducy P, Karsenty G (2000).
"The family of bone morphogenetic proteins" . Kidney Int . 57 (6): 2207–14.
doi :
10.1046/j.1523-1755.2000.00081.x .
PMID
10844590 .
Grupe A, Li Y, Rowland C, et al. (2006).
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease" . Am. J. Hum. Genet . 78 (1): 78–88.
doi :
10.1086/498851 .
PMC
1380225 .
PMID
16385451 .
Hino J, Takao M, Takeshita N, et al. (1996). "cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b)". Biochem. Biophys. Res. Commun . 223 (2): 304–10.
doi :
10.1006/bbrc.1996.0889 .
PMID
8670277 .
Zhou M, Lucas DA, Chan KC, et al. (2004). "An investigation into the human serum "interactome" ". Electrophoresis . 25 (9): 1289–98.
doi :
10.1002/elps.200405866 .
PMID
15174051 .
S2CID
42449980 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Kimura K, Toyooka S, Tsukuda K, et al. (2008).
"The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas" . Oncol. Rep . 20 (5): 1265–8.
doi :
10.3892/or_00000139 .
PMID
18949431 .
Lafont JE, Talma S, Hopfgarten C, Murphy CL (2008).
"Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways" . J. Biol. Chem . 283 (8): 4778–86.
doi :
10.1074/jbc.M707729200 .
PMID
18077449 .
Type I
ALK1 (
ACVRL1 )
ALK2 (
ACVR1A )
ALK3 (
BMPR1A )
ALK4 (
ACVR1B )
ALK5 (
TGFβR1 )
ALK6 (
BMPR1B )
Agonists:
BMP (
2 ,
4 ,
5 ,
6 ,
7 ,
8A ,
8B ,
15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) ,
9 ,
15 )
Radotermin
ALK7 (
ACVR1C )
Type II
TGFβR2
BMPR2
ACVR2A (
ACVR2 )
Agonists:
Activin (
A ,
B ,
AB )
BMP (
2 ,
4 ,
5 ,
6 ,
7 ,
8A ,
8B ,
15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (
1 ,
3 ,
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) ,
9 ,
11 (BMP11) ,
15 )
Myostatin (GDF8)
Nodal
Radotermin
ACVR2B
Agonists:
Activin (
A ,
B ,
AB )
BMP (
2 ,
4 ,
6 ,
7 )
Dibotermin alfa
Eptotermin alfa
GDF (
1 ,
3 ,
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Radotermin
AMHR2 (
AMHR )
Type III
Unsorted