From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Bone morphogenetic protein 8A (BMP8A ) is a
protein that in humans is encoded by the BMP8A
gene .
[5]
BMP8A is a polypeptide member of the
TGFβ superfamily of proteins. It, like other
bone morphogenetic proteins (BMPs), is involved in the development of bone and cartilage. BMP8A may be involved in
epithelial
osteogenesis . It also plays a role in bone
homeostasis . It is a
disulfide -linked
homodimer .
References
External links
Further reading
Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun . 11 (3): 232–8.
doi :
10.1038/gene.2010.1 .
PMID
20237496 .
S2CID
11183658 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Gregory SG, Barlow KF, McLay KE, et al. (2006).
"The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21.
Bibcode :
2006Natur.441..315G .
doi :
10.1038/nature04727 .
PMID
16710414 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Type I
ALK1 (
ACVRL1 )
ALK2 (
ACVR1A )
ALK3 (
BMPR1A )
ALK4 (
ACVR1B )
ALK5 (
TGFβR1 )
ALK6 (
BMPR1B )
Agonists:
BMP (
2 ,
4 ,
5 ,
6 ,
7 ,
8A ,
8B ,
15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) ,
9 ,
15 )
Radotermin
ALK7 (
ACVR1C )
Type II
TGFβR2
BMPR2
ACVR2A (
ACVR2 )
Agonists:
Activin (
A ,
B ,
AB )
BMP (
2 ,
4 ,
5 ,
6 ,
7 ,
8A ,
8B ,
15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (
1 ,
3 ,
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) ,
9 ,
11 (BMP11) ,
15 )
Myostatin (GDF8)
Nodal
Radotermin
ACVR2B
Agonists:
Activin (
A ,
B ,
AB )
BMP (
2 ,
4 ,
6 ,
7 )
Dibotermin alfa
Eptotermin alfa
GDF (
1 ,
3 ,
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Radotermin
AMHR2 (
AMHR )
Type III
Unsorted