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Routes of administration | Oral |
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Formula | C10H14ClN |
Molar mass | 183.68 g·mol−1 |
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NY (what is this?) (verify) |
4-Chlorophenylisobutylamine (4-CAB, AEPCA), also known as 4-chloro-α-ethylphenethylamine, is an entactogen and stimulant drug of the phenethylamine class. [1] It is an analogue of para-chloroamphetamine (PCA) where the alpha position methyl has been replaced with an ethyl group. [1]
In comparison to PCA, 4-CAB is approximately 2- and 5-fold less potent at inhibiting the reuptake of serotonin ( IC50 = 330 nM) and dopamine (IC50 = 2,343 nM), respectively, and is about 3-fold less potent in substituting for MDMA in animals in drug discrimination assays. [1] Though its dopaminergic activity is significantly attenuated compared to PCA, unlike the case of MBDB, it is not abolished[ clarification needed], and is actually similar to that of MDMA. [1]
Relative to PCA, 4-CAB is also substantially less effective as a serotonergic neurotoxin. [1] A single 10 mg/kg administration of PCA to rats produces an approximate 80% decrease in serotonin markers as observed 1 week later. [1] In contrast, 11 mg/kg and 22 mg/kg doses of 4-CAB result in only 20% and 50% decreases, respectively. [1] This is once again similar to MDMA which causes a 40-60% reduction with a single 20 mg/kg dose. [2]
Phenylalkyl- amines (other than cathinones) |
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phenyl- alkylamines | |
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Phenethylamines |
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Amphetamines |
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Phentermines |
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Cathinones |
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Phenylisobutylamines | |
Phenylalkylpyrrolidines | |
Catecholamines (and close relatives) |
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Miscellaneous |
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