PKN3 is a
protein kinase C-related molecule and thought to be an
effector mediating
malignant cell growth downstream of activated phosphoinositide 3-kinase (
PI3K).[5] It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/
PTENsignal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.
1
PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (
shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
^Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (July 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry. 130 (1): 23–31.
doi:
10.1093/oxfordjournals.jbchem.a002958.
PMID11432776.
Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (July 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry. 130 (1): 23–31.
doi:
10.1093/oxfordjournals.jbchem.a002958.
PMID11432776.
Oishi K, Mukai H, Shibata H, Takahashi M, Ona Y (August 1999). "Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha". Biochemical and Biophysical Research Communications. 261 (3): 808–14.
doi:
10.1006/bbrc.1999.1116.
PMID10441506.
