PNU-99,194(A) (or U-99,194(A)) is a
drug which acts as a moderately
selectiveD3 receptorantagonist with ~15-30-fold preference for D3 over the
D2 subtype.[1][2][3] Though it has substantially greater preference for D3 over D2, the latter receptor does still play some role in its effects, as evidenced by the fact that PNU-99,194 weakly stimulates both
prolactinsecretion and
striataldopaminesynthesis, actions it does not share with the more selective (100-fold) D3 receptor antagonists
S-14,297 and
GR-103,691.[4]
^
abClaytor R, Lile JA, Nader MA (March 2006). "The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys". Pharmacology Biochemistry and Behavior. 83 (3): 456–64.
doi:
10.1016/j.pbb.2006.03.007.
PMID16631246.
S2CID39482275.
^
abWaters N, Svensson K, Haadsma-Svensson SR, Smith MW, Carlsson A (1993). "The dopamine D3-receptor: a postsynaptic receptor inhibitory on rat locomotor activity". Journal of Neural Transmission. General Section. 94 (1): 11–9.
doi:
10.1007/bf01244979.
PMID8129881.
S2CID32918280.
^
abKling-Petersen T, Ljung E, Svensson K (1995). "Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain". Journal of Neural Transmission. General Section. 102 (3): 209–20.
doi:
10.1007/bf01281155.
PMID8788069.
S2CID10327706.
^
abKling-Petersen T, Ljung E, Wollter L, Svensson K (1995). "Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat". Journal of Neural Transmission. General Section. 101 (1–3): 27–39.
doi:
10.1007/bf01271543.
PMID8695055.
S2CID30848393.
^
abcFrancès H, Smirnova M, Leriche L, Sokoloff P (September 2004). "Dopamine D3 receptor ligands modulate the acquisition of morphine-conditioned place preference". Psychopharmacology. 175 (2): 127–33.
doi:
10.1007/s00213-004-1807-9.
PMID15095031.
S2CID2721240.
^
abcKhroyan TV, Baker DA, Neisewander JL (December 1995). "Dose-dependent effects of the D3-preferring agonist 7-OH-DPAT on motor behaviors and place conditioning". Psychopharmacology. 122 (4): 351–7.
doi:
10.1007/BF02246265.
PMID8657832.
S2CID20542615.
^
abMillan MJ, Seguin L, Gobert A, Cussac D, Brocco M (July 2004). "The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats". Psychopharmacology. 174 (3): 341–57.
doi:
10.1007/s00213-003-1770-x.
PMID14985929.
S2CID1592299.
^
abCasarrubea M, Sorbera F, Crescimanno G (November 2006). "Effects of 7-OH-DPAT and U 99194 on the behavioral response to hot plate test, in rats". Physiology & Behavior. 89 (4): 552–62.
doi:
10.1016/j.physbeh.2006.07.014.
PMID16919688.
S2CID45464906.
^Boulay D, Depoortere R, Rostene W, Perrault G, Sanger DJ (April 1999). "Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice". Neuropharmacology. 38 (4): 555–65.
doi:
10.1016/S0028-3908(98)00213-5.
PMID10221759.
S2CID1004412.
^Rogóz Z, Kłodzińska A, Maj J (2000). "Anxiolytic-like effect of nafadotride and PNU 99194A, dopamine D3 receptor antagonists in animal models". Polish Journal of Pharmacology. 52 (6): 459–62.
PMID11334239.
^Laszy J, Laszlovszky I, Gyertyán I (May 2005). "Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats". Psychopharmacology. 179 (3): 567–75.
doi:
10.1007/s00213-004-2096-z.
PMID15619116.
S2CID24086632.
^Hammad H, Wagner JJ (January 2006). "Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation". The Journal of Pharmacology and Experimental Therapeutics. 316 (1): 113–20.
doi:
10.1124/jpet.105.091579.
PMID16162819.
S2CID10007327.
^Carr KD, Yamamoto N, Omura M, Cabeza de Vaca S, Krahne L (August 2002). "Effects of the D(3) dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats". Psychopharmacology. 163 (1): 76–84.
doi:
10.1007/s00213-002-1132-0.
PMID12185403.
S2CID1840764.
^Chiang YC, Chen PC, Chen JC (May 2003). "D(3) dopamine receptors are down-regulated in amphetamine sensitized rats and their putative antagonists modulate the locomotor sensitization to amphetamine". Brain Research. 972 (1–2): 159–67.
doi:
10.1016/S0006-8993(03)02522-8.
PMID12711089.
S2CID40067321.
^Gál K, Gyertyán I (October 2003). "Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats". Brain Research Bulletin. 61 (6): 595–601.
doi:
10.1016/S0361-9230(03)00217-X.
PMID14519456.
S2CID12383682.