Quinagolide (
INNTooltip International nonproprietary name,
BANTooltip British Approved Name), sold under the brand name Norprolac, is a
selectivedopamineD2 receptoragonist which is used to reduce elevated levels of
prolactin (
hyperprolactinemia).[1] It has also been found to be effective in the treatment of
breast pain.[2] It is used in the UK, but it is not available in US.
Chemistry
Quinagolide is a
racemate composed of the following two enantiomers:[3]
Enantiomeres of Quinagolide
(+)-Quinagolid CAS number: 140630-79-1
(-)-Quinagolid CAS number: 140630-80-4
References
^Di Sarno A, Landi ML, Marzullo P, Di Somma C, Pivonello R, Cerbone G, et al. (July 2000). "The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas". Clinical Endocrinology. 53 (1): 53–60.
doi:
10.1046/j.1365-2265.2000.01016.x.
PMID10931080.
S2CID31677949.
^Rote Liste Service GmbH (Hrsg.) (2017). Rote Liste 2017 - Arzneimittelverzeichnis für Deutschland (einschließlich EU-Zulassungen und bestimmter Medizinprodukte) [Red List 2017 - List of medicinal products for Germany (including EU approvals and certain medical devices)] (in German) (57th ed.). Frankfurt/Main: Rote Liste Service GmbH. p. 214.
ISBN978-3-946057-10-9.