From Wikipedia, the free encyclopedia
Chemical compound
L-745,870 is a drug which acts as a
dopamine
receptor
antagonist selective for the
D4 subtype, and has
antipsychotic effects in animal models, though it was not effective in human trials.
[1]
[2]
[3]
References
-
^ Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences. 18 (6): 186–8.
doi:
10.1016/s0165-6147(97)01066-3.
PMID
9226994.
-
^ Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004).
"Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology. 29 (9): 1648–55.
doi:
10.1038/sj.npp.1300491.
PMID
15138447.
-
^ Moustgaard A, Hau J, Lind NM (2008).
"Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions. 4: 49.
doi:
10.1186/1744-9081-4-49.
PMC
2577092.
PMID
18945334.