Chanoclavine, also known as chanoclavin-l is a tri-cyclic ergot alkaloid (
ergoline) isolate of certain fungi. It is mainly produced by members of the genus
claviceps.[1] Long used in traditional Chinese medicine, it was found in 1987 mouse studies to stimulate dopamine
D2 receptors in the brain.[2]
^Lorenz, N; Haarmann, T; Pazoutová, S; Jung, M; Tudzynski, P (2009). "The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects". Phytochemistry. 70 (15–16): 1822–32.
doi:
10.1016/j.phytochem.2009.05.023.
PMID19695648.
^Watanabe, H; Somei, M; Sekihara, S; Nakagawa, K; Yamada, F (1987). "Dopamine receptor stimulating effects of chanoclavine analogues, tricyclic ergot alkaloids, in the brain". Japanese Journal of Pharmacology. 45 (4): 501–6.
doi:
10.1254/jjp.45.501.
PMID3127619.