From Wikipedia, the free encyclopedia
Chemical compound
ORG-25435 is a synthetic
drug developed by
Organon International, which acts as a
GABAA receptor
positive allosteric modulator, and produces
sedative effects. It has been researched for use as an intravenous
anesthetic agent, with positive results in initial trials, although negative side effects like
hypotension and
tachycardia, as well as unpredictable
pharmacokinetics at higher doses, have meant it has ultimately not been adopted for medical use.
[1]
[2]
References
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^ Anderson A, Belelli D, Bennett DJ, Buchanan KI, Casula A, Cooke A, et al. (October 2001). "Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors". Journal of Medicinal Chemistry. 44 (22): 3582–91.
doi:
10.1021/jm010903i.
PMID
11606122.
-
^ Rigby-Jones AE, Sneyd JR, Vijn P, Boen P, Cross M (June 2010).
"First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial". BMC Anesthesiology. 10: 10.
doi:
10.1186/1471-2253-10-10.
PMC
2914736.
PMID
20587019.
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