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Chemical compound
Afloqualone (Arofuto) is a
quinazolinone family
GABAergic
drug and is an analogue of
methaqualone developed in the 1970s by a team at Tanabe Seiyaku.
[1] It has
sedative and
muscle-relaxant effects resulting from its agonist activity at the β subtype of the
GABAa receptor
[2] and has had some clinical use, although it causes
photosensitization as a side-effect that can cause skin problems such as
dermatitis .
[3]
See also
References
^
US 3966731 , Inoue I, Oine T, Yamada Y, Tani J, Ishida R, Ochiai T, "2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone", issued 29 June 1976, assigned to Tanabe Seiyaku Co Ltd
^ Ochiai T, Ishida R (June 1982).
"Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity" . Japanese Journal of Pharmacology . 32 (3): 427–38.
doi :
10.1254/jjp.32.427 .
PMID
7109348 .
^ Ishikawa T, Kamide R, Niimura M (June 1994). "Photoleukomelanodermatitis (Kobori) induced by afloqualone". The Journal of Dermatology . 21 (6): 430–3.
doi :
10.1111/j.1346-8138.1994.tb01768.x .
PMID
8064007 .
S2CID
7486566 .
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