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Chemical compound
Mebutamate (Capla , Dormate ) is an
anxiolytic and
sedative
drug with
antihypertensive effects of the carbamate class.
[1]
[2] It has effects comparable to those of
barbiturates such as
secobarbital , but is only around 1/3 the potency of secobarbital as a sedative. Side effects include
dizziness and
headaches .
[3]
Mebutamate is one of many
GABAergic drugs which act via
allosteric agonism of the
GABAA receptor at the β-subreceptor similar to barbiturates. In contrast,
benzodiazepines act at the α-subreceptor. As such, carbamates and barbiturates, possess
analgesic properties while the benzodiazepine class of drugs are strictly psychoactive.
Other carbamates with the same mechanism of action and pharmacological properties include
meprobamate ,
carisoprodol ,
felbamate , and
tybamate .
Synthesis
Mebutamate synthesis: Berger, Ludwig,
U.S. patent 2,878,280 (1959 to
Carter Prod .).
Structural analogs
References
Alcohols
Barbiturates
Benzodiazepines
Carbamates
Flavonoids
Imidazoles
Kava constituents
Monoureides
Neuroactive steroids
Nonbenzodiazepines
Phenols
Piperidinediones
Pyrazolopyridines
Quinazolinones
Volatiles /
gases Others/unsorted
3-Hydroxybutanal
α-EMTBL
AA-29504
Alogabat
Avermectins (e.g.,
ivermectin )
Bromide compounds (e.g.,
lithium bromide ,
potassium bromide ,
sodium bromide )
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
Darigabat
DEABL
Deuterated etifoxine
Dihydroergolines (e.g.,
dihydroergocryptine ,
dihydroergosine ,
dihydroergotamine ,
ergoloid (dihydroergotoxine) )
DS2
Efavirenz
Etazepine
Etifoxine
Fenamates (e.g.,
flufenamic acid ,
mefenamic acid ,
niflumic acid ,
tolfenamic acid )
Fluoxetine
Flupirtine
Hopantenic acid
KRM-II-81
Lanthanum
Lavender oil
Lignans (e.g.,
4-O-methylhonokiol ,
honokiol ,
magnolol ,
obovatol )
Loreclezole
Menthyl isovalerate (validolum)
Monastrol
Niacin
Niacinamide
Org 25,435
Phenytoin
Propanidid
Retigabine (ezogabine)
Safranal
Seproxetine
Stiripentol
Sulfonylalkanes (e.g.,
sulfonmethane (sulfonal) ,
tetronal ,
trional )
Terpenoids (e.g.,
borneol )
Topiramate
Valerian constituents (e.g.,
isovaleric acid ,
isovaleramide ,
valerenic acid ,
valerenol )