Phenprobamate (Gamaquil, Isotonil, Actozine) is a centrally acting
skeletalmuscle relaxant, with additional
sedative and
anticonvulsant effects.[2][unreliable source?] Overdose is similar to
barbiturates. Its
mechanism of action is probably similar to
meprobamate. Phenprobamate has been used in humans as an
anxiolytic, and is still sometimes used in
general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the
carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.[citation needed]
Doses range from 400 to 800 mg, up to 3 times a day.[3]
^Demir B, Demir Y, Aksoy I, Kilic OH, Gucyetmez V, Savas HA (June 2015). "Phenprobamate dependence: a case report". Addictive Behaviors. 45: 232–3.
doi:
10.1016/j.addbeh.2015.01.037.
PMID25727392.