Irazepine (Ro 7-1986/1) is a
benzodiazepine derivative containing
isothiocyanate functional group.[1] It is a non-competitive benzodiazepine binding site antagonist.[2] Irazepine and other alkylating benzodiazepines, such as
kenazepine, bind to brain
benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting
anticonvulsant effect.[3]
^Hall IK, Morton JM (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. p. 156.
ISBN978-94-011-4439-1.
^Williams EF, Rice KC, Mattson M, Paul SM, Skolnick P (April 1981). "In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine". Pharmacology, Biochemistry, and Behavior. 14 (4): 487–91.
doi:
10.1016/0091-3057(81)90307-5.
PMID7232472.
S2CID22221220.