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CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.048.694 |
Chemical and physical data | |
Formula | C18H17ClN2O3 |
Molar mass | 344.80 g·mol−1 |
3D model ( JSmol) | |
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NY (what is this?) (verify) |
Arfendazam ( INN) [1] is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.
Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABAA receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses. [2] [3]
Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects. [4]
Anxiolytics (
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5-HT1ARTooltip 5-HT1A receptor agonists | |
GABAARTooltip GABAA receptor PAMsTooltip positive allosteric modulators |
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Gabapentinoids ( α2δ VDCC blockers) | |
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1,4-Benzodiazepines |
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Triazolobenzodiazepines | |
Imidazobenzodiazepines | |
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Thienobenzodiazepines* | |
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Pyrazolodiazepines | |
Pyrrolodiazepines | |
Tetrahydroisoquinobenzodiazepines | |
Pyrrolobenzodiazepines* | |
Benzodiazepine prodrugs | |
* atypical activity profile (not
GABAA receptor ligands) |
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Others/unsorted |
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