U-89843A (PNU-89843) is a
sedative drug which acts as an
agonist at
GABAAreceptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes.[1] It has sedative effects in animals but without causing
ataxia, and also acts as an
antioxidant and may have
neuroprotective effects.[2] It was developed by a team at Upjohn in the 1990s.[3]
References
^Im HK, Im WB, Pregenzer JF, Carter DB, Hamilton BJ (December 1995). "U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors". The Journal of Pharmacology and Experimental Therapeutics. 275 (3): 1390–5.
PMID8531107.
^Bundy GL, Ayer DE, Banitt LS, Belonga KL, Mizsak SA, Palmer JR, et al. (October 1995). "Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity". Journal of Medicinal Chemistry. 38 (21): 4161–3.
doi:
10.1021/jm00021a004.
PMID7473542.
^US 5502187, "Pharmaceutically active bicyclic-heterocyclic amines"