From Wikipedia, the free encyclopedia
Chemical compound
Bromisoval (
INN ), commonly known as bromovalerylurea , is a
hypnotic and
sedative of the
bromoureide group discovered by Knoll in 1907 and patented in 1909.
[1] It is marketed
over the counter in Asia under various trade names (such as Brovarin
[2] ), usually in combination with
nonsteroidal anti-inflammatory drugs .
Chronic use of bromisoval has been associated with
bromine poisoning.
[3]
[4]
[5]
[6]
Bromisoval can be prepared by bromination of
isovaleric acid by the
Hell-Volhard-Zelinsky reaction followed by reaction with
urea .
See also
References
^
US patent 914518 , Saam, E., "Alpha-halogen-isovaleryl-urea and process of making the same", issued 1909-03-09, assigned to Knoll
^
"Bromisoval" . International . Drugs.com.
^ Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001).
"市販鎮痛剤常用量の服用による慢性ブロム中毒の1例" [A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia] (pdf) . Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (in Japanese). 38 (5): 700–703.
doi :
10.3143/geriatrics.38.700 .
ISSN
0300-9173 .
PMID
11605223 .
^ Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998).
"Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse" (pdf) . Internal Medicine . 37 (9). Tokyo, Japan: 788–791.
doi :
10.2169/internalmedicine.37.788 .
PMID
9804091 .
^ Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005).
"Pseudohyperchloraemia due to bromvalerylurea abuse" . Nephrology Dialysis Transplantation . 20 (8): 1767–1768.
doi :
10.1093/ndt/gfh945 .
PMID
15972320 .
^ Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997).
"Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning" (pdf) . Internal Medicine . 36 (10). Tokyo, Japan: 742–746.
doi :
10.2169/internalmedicine.36.742 .
PMID
9372340 .
Alcohols
Barbiturates
Benzodiazepines
Carbamates
Flavonoids
Imidazoles
Kava constituents
Monoureides
Neuroactive steroids
Nonbenzodiazepines
Phenols
Piperidinediones
Pyrazolopyridines
Quinazolinones
Volatiles /
gases Others/unsorted
3-Hydroxybutanal
α-EMTBL
AA-29504
Alogabat
Avermectins (e.g.,
ivermectin )
Bromide compounds (e.g.,
lithium bromide ,
potassium bromide ,
sodium bromide )
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
Darigabat
DEABL
Deuterated etifoxine
Dihydroergolines (e.g.,
dihydroergocryptine ,
dihydroergosine ,
dihydroergotamine ,
ergoloid (dihydroergotoxine) )
DS2
Efavirenz
Etazepine
Etifoxine
Fenamates (e.g.,
flufenamic acid ,
mefenamic acid ,
niflumic acid ,
tolfenamic acid )
Fluoxetine
Flupirtine
Hopantenic acid
KRM-II-81
Lanthanum
Lavender oil
Lignans (e.g.,
4-O-methylhonokiol ,
honokiol ,
magnolol ,
obovatol )
Loreclezole
Menthyl isovalerate (validolum)
Monastrol
Niacin
Niacinamide
Org 25,435
Phenytoin
Propanidid
Retigabine (ezogabine)
Safranal
Seproxetine
Stiripentol
Sulfonylalkanes (e.g.,
sulfonmethane (sulfonal) ,
tetronal ,
trional )
Terpenoids (e.g.,
borneol )
Topiramate
Valerian constituents (e.g.,
isovaleric acid ,
isovaleramide ,
valerenic acid ,
valerenol )