Even though
Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether propanidid itself may have contributed to the reactions.
It has been argued that the toxic effects or reactions to propanidid (and
Althesin) were due to the drugs themselves.[3] Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer, suggesting that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.
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Zawisza P, Przyborowski L (1992). "[Propanidid and etomidate identification from the blood by thin-layer chromatography]". Acta Poloniae Pharmaceutica. 49 (5–6): 15–17.
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Theis JG, Liau-Chu M, Chan HS, Doyle J, Greenberg ML, Koren G (October 1995). "Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of Cremophor EL". Journal of Clinical Oncology. 13 (10): 2508–2516.
doi:
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PMID7595701.
Ebo DG, Piel GC, Conraads V, Stevens WJ (September 2001). "IgE-mediated anaphylaxis after first intravenous infusion of cyclosporine". Annals of Allergy, Asthma & Immunology. 87 (3): 243–245.
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PMID11570623.